FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022365217> ?p ?o ?g. }

• W2022365217 abstract "Although hydroxyurea (HU) has been used clinically to treat patients with sickle cell disease (SCD), not all patients benefit from HU treatment due to its toxicity. The objective of this study was to investigate the effectiveness of the use of two new Hb F-inducing nitrosourea analogues, 2-[3-(2-methyl, 2-nitroso) ureido]-2-deoxy-D-glucopyranose (MNGU) and 2-[3-(2-chloroethyl) ureido]-2-deoxy-D-glucopyranose (CGU), in combination with HU in K562 cells or erythroid progenitors.After K562 cells were cultured with different concentrations of HU with CGU or MNGU, aliquots of the cells were obtained to determine the total (benzidine-positive) hemoglobin level, number of F cells, and Hb F level. Erythroid progenitor cells of SCD patients and healthy donors were cultured with the optimal drug concentrations, and the number of BFU-E and Hb F level were determined.Our results showed that the combined use of HU with CGU or MNGU increased the number of both benzidine-positive normoblasts and F cells in a synergistic manner. Further, a lower concentration of HU was required to induce a significant level of Hb F synthesis when combined with either of the two compounds in comparison with treatment with HU alone. On day 4, the number of benzidine-positive cells was 4.5- to 6.5-fold and the number of F cells was 5.0- to 8.0-fold higher than the respective numbers in the untreated K562 cells. Similarly, a 3.2- to 14.3-fold induction of Hb F was obtained when human erythroid progenitors from SCD patients were treated with the same drug combinations.Based on these results, the use of CGU or MNGU in combination with HU might offer substantial benefits to patients with SCD and other hemoglobinopathies." @default.
• W2022365217 created "2016-06-24" @default.
• W2022365217 creator A5001069055 @default.
• W2022365217 creator A5002216474 @default.
• W2022365217 creator A5040797037 @default.
• W2022365217 creator A5042696665 @default.
• W2022365217 creator A5052634935 @default.
• W2022365217 creator A5061457736 @default.
• W2022365217 creator A5064895264 @default.
• W2022365217 creator A5068998171 @default.
• W2022365217 date "2003-07-01" @default.
• W2022365217 modified "2023-10-17" @default.
• W2022365217 title "Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line" @default.
• W2022365217 cites W1488638920 @default.
• W2022365217 cites W1556432187 @default.
• W2022365217 cites W1560101975 @default.
• W2022365217 cites W1579641819 @default.
• W2022365217 cites W1580764938 @default.
• W2022365217 cites W1724131118 @default.
• W2022365217 cites W1789486470 @default.
• W2022365217 cites W1968179962 @default.
• W2022365217 cites W1972148557 @default.
• W2022365217 cites W1979569154 @default.
• W2022365217 cites W1980527613 @default.
• W2022365217 cites W1984169753 @default.
• W2022365217 cites W1995550655 @default.
• W2022365217 cites W1996043889 @default.
• W2022365217 cites W2000881989 @default.
• W2022365217 cites W200707284 @default.
• W2022365217 cites W2019578579 @default.
• W2022365217 cites W2027948486 @default.
• W2022365217 cites W2028648417 @default.
• W2022365217 cites W2034672274 @default.
• W2022365217 cites W2042567177 @default.
• W2022365217 cites W2066875500 @default.
• W2022365217 cites W2071707384 @default.
• W2022365217 cites W2072089033 @default.
• W2022365217 cites W2077945404 @default.
• W2022365217 cites W2084586855 @default.
• W2022365217 cites W2095892107 @default.
• W2022365217 cites W2101955568 @default.
• W2022365217 cites W2136829438 @default.
• W2022365217 cites W2149685508 @default.
• W2022365217 cites W2164574288 @default.
• W2022365217 cites W2313825712 @default.
• W2022365217 cites W2323938126 @default.
• W2022365217 cites W2339887069 @default.
• W2022365217 cites W2412180384 @default.
• W2022365217 cites W2417935715 @default.
• W2022365217 cites W2464605913 @default.
• W2022365217 cites W324137543 @default.
• W2022365217 cites W51066043 @default.
• W2022365217 cites W589871947 @default.
• W2022365217 doi "https://doi.org/10.1016/s0301-472x(03)00105-x" @default.
• W2022365217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12842704" @default.
• W2022365217 hasPublicationYear "2003" @default.
• W2022365217 type Work @default.
• W2022365217 sameAs 2022365217 @default.
• W2022365217 citedByCount "6" @default.
• W2022365217 countsByYear W20223652172013 @default.
• W2022365217 crossrefType "journal-article" @default.
• W2022365217 hasAuthorship W2022365217A5001069055 @default.
• W2022365217 hasAuthorship W2022365217A5002216474 @default.
• W2022365217 hasAuthorship W2022365217A5040797037 @default.
• W2022365217 hasAuthorship W2022365217A5042696665 @default.
• W2022365217 hasAuthorship W2022365217A5052634935 @default.
• W2022365217 hasAuthorship W2022365217A5061457736 @default.
• W2022365217 hasAuthorship W2022365217A5064895264 @default.
• W2022365217 hasAuthorship W2022365217A5068998171 @default.
• W2022365217 hasBestOaLocation W20223652171 @default.
• W2022365217 hasConcept C1491633281 @default.
• W2022365217 hasConcept C153911025 @default.
• W2022365217 hasConcept C171122931 @default.
• W2022365217 hasConcept C172680121 @default.
• W2022365217 hasConcept C185592680 @default.
• W2022365217 hasConcept C201750760 @default.
• W2022365217 hasConcept C203014093 @default.
• W2022365217 hasConcept C2776317666 @default.
• W2022365217 hasConcept C2778917026 @default.
• W2022365217 hasConcept C2779234561 @default.
• W2022365217 hasConcept C2780267503 @default.
• W2022365217 hasConcept C28328180 @default.
• W2022365217 hasConcept C54355233 @default.
• W2022365217 hasConcept C55493867 @default.
• W2022365217 hasConcept C71924100 @default.
• W2022365217 hasConcept C81885089 @default.
• W2022365217 hasConcept C86803240 @default.
• W2022365217 hasConcept C95444343 @default.
• W2022365217 hasConcept C98274493 @default.
• W2022365217 hasConceptScore W2022365217C1491633281 @default.
• W2022365217 hasConceptScore W2022365217C153911025 @default.
• W2022365217 hasConceptScore W2022365217C171122931 @default.
• W2022365217 hasConceptScore W2022365217C172680121 @default.
• W2022365217 hasConceptScore W2022365217C185592680 @default.
• W2022365217 hasConceptScore W2022365217C201750760 @default.
• W2022365217 hasConceptScore W2022365217C203014093 @default.
• W2022365217 hasConceptScore W2022365217C2776317666 @default.
• W2022365217 hasConceptScore W2022365217C2778917026 @default.
• W2022365217 hasConceptScore W2022365217C2779234561 @default.
• W2022365217 hasConceptScore W2022365217C2780267503 @default.

• next