Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022366125> ?p ?o ?g. }
- W2022366125 endingPage "1050" @default.
- W2022366125 startingPage "1043" @default.
- W2022366125 abstract "According to recent studies, the function of Slug in hypoxia induced cadherin switch differs from cancer to cancer. Whether Slug is an essential mediator of the tumor hypoxia induced cadherin switch in head and neck squamous cell carcinoma (HNSCC) and the prognostic role of Slug in HNSCC patients are not elucidated. The aim of this study is to investigate the role of the Slug in cadherin switch induced by hypoxia in HNSCC.Two HNSCC cell lines and 119 HNSCC specimens were selected for the present experiments. E/N-cadherins expression and tumor cell invasion responding to hypoxia/HIF-1α overexpression and the silence of Slug/SnaI2 gene were detected in vitro. HNSCC specimens were analyzed by immunohistochemistry staining to correlate the expressions of Slug, HIF-1α and E/N-cadherins with clinical outcomes.Our research evidenced that Slug was extremely elevated in the HNSCC cells in response to hypoxia/HIF-1α overexpression. Suppressing Slug expression impaired HIF-1α induced cadherin switch and tumor invasion. In HNSCC tissues, relatively high expression of Slug was detected to be associated with endogenous HIF-1α overexpression, cadherin switch, the risk of lymph node metastasis, and a more advanced TNM stage. Additionally, aberrant Slug expression combined with HIF-1α overexpression and cadherin switch was significantly correlated with shorter HNSCC patient survival. In conclusion, Slug is necessary for hypoxia-induced cadherin switch in HNSCC and may be used as a potential risk marker in predicting HNSCC clinical outcomes." @default.
- W2022366125 created "2016-06-24" @default.
- W2022366125 creator A5020920311 @default.
- W2022366125 creator A5025633927 @default.
- W2022366125 creator A5032273514 @default.
- W2022366125 creator A5077863311 @default.
- W2022366125 creator A5091841028 @default.
- W2022366125 date "2013-11-01" @default.
- W2022366125 modified "2023-10-16" @default.
- W2022366125 title "Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: Correlations with poor prognosis" @default.
- W2022366125 cites W1481881961 @default.
- W2022366125 cites W1965255998 @default.
- W2022366125 cites W1967532587 @default.
- W2022366125 cites W1979858258 @default.
- W2022366125 cites W1979909585 @default.
- W2022366125 cites W1980229989 @default.
- W2022366125 cites W1985688210 @default.
- W2022366125 cites W1986396179 @default.
- W2022366125 cites W1995480433 @default.
- W2022366125 cites W2025918688 @default.
- W2022366125 cites W2027497744 @default.
- W2022366125 cites W2033148943 @default.
- W2022366125 cites W2043140203 @default.
- W2022366125 cites W2052473734 @default.
- W2022366125 cites W2053880555 @default.
- W2022366125 cites W2057967439 @default.
- W2022366125 cites W2058324214 @default.
- W2022366125 cites W2058667985 @default.
- W2022366125 cites W2062070329 @default.
- W2022366125 cites W2071609983 @default.
- W2022366125 cites W2075054245 @default.
- W2022366125 cites W2075093878 @default.
- W2022366125 cites W2087367170 @default.
- W2022366125 cites W2088402290 @default.
- W2022366125 cites W2092762721 @default.
- W2022366125 cites W2094644721 @default.
- W2022366125 cites W2095337379 @default.
- W2022366125 cites W2101121084 @default.
- W2022366125 cites W2104108149 @default.
- W2022366125 cites W2107876629 @default.
- W2022366125 cites W2118650242 @default.
- W2022366125 cites W2125917736 @default.
- W2022366125 cites W2130475919 @default.
- W2022366125 cites W2134361367 @default.
- W2022366125 cites W2135913014 @default.
- W2022366125 cites W2146654096 @default.
- W2022366125 cites W2147283821 @default.
- W2022366125 cites W2158164219 @default.
- W2022366125 cites W2161728771 @default.
- W2022366125 cites W2162419324 @default.
- W2022366125 cites W2327922861 @default.
- W2022366125 cites W4211224216 @default.
- W2022366125 cites W4362223593 @default.
- W2022366125 doi "https://doi.org/10.1016/j.oraloncology.2013.08.003" @default.
- W2022366125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24035721" @default.
- W2022366125 hasPublicationYear "2013" @default.
- W2022366125 type Work @default.
- W2022366125 sameAs 2022366125 @default.
- W2022366125 citedByCount "50" @default.
- W2022366125 countsByYear W20223661252014 @default.
- W2022366125 countsByYear W20223661252015 @default.
- W2022366125 countsByYear W20223661252016 @default.
- W2022366125 countsByYear W20223661252017 @default.
- W2022366125 countsByYear W20223661252018 @default.
- W2022366125 countsByYear W20223661252019 @default.
- W2022366125 countsByYear W20223661252020 @default.
- W2022366125 countsByYear W20223661252021 @default.
- W2022366125 countsByYear W20223661252022 @default.
- W2022366125 countsByYear W20223661252023 @default.
- W2022366125 crossrefType "journal-article" @default.
- W2022366125 hasAuthorship W2022366125A5020920311 @default.
- W2022366125 hasAuthorship W2022366125A5025633927 @default.
- W2022366125 hasAuthorship W2022366125A5032273514 @default.
- W2022366125 hasAuthorship W2022366125A5077863311 @default.
- W2022366125 hasAuthorship W2022366125A5091841028 @default.
- W2022366125 hasConcept C121608353 @default.
- W2022366125 hasConcept C126322002 @default.
- W2022366125 hasConcept C142724271 @default.
- W2022366125 hasConcept C1491633281 @default.
- W2022366125 hasConcept C149402561 @default.
- W2022366125 hasConcept C178790620 @default.
- W2022366125 hasConcept C185592680 @default.
- W2022366125 hasConcept C204232928 @default.
- W2022366125 hasConcept C2776530083 @default.
- W2022366125 hasConcept C2776833033 @default.
- W2022366125 hasConcept C2779013556 @default.
- W2022366125 hasConcept C2781381752 @default.
- W2022366125 hasConcept C502942594 @default.
- W2022366125 hasConcept C540031477 @default.
- W2022366125 hasConcept C54355233 @default.
- W2022366125 hasConcept C71924100 @default.
- W2022366125 hasConcept C7836513 @default.
- W2022366125 hasConcept C86803240 @default.
- W2022366125 hasConceptScore W2022366125C121608353 @default.
- W2022366125 hasConceptScore W2022366125C126322002 @default.
- W2022366125 hasConceptScore W2022366125C142724271 @default.
- W2022366125 hasConceptScore W2022366125C1491633281 @default.
- W2022366125 hasConceptScore W2022366125C149402561 @default.