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- W2022367208 abstract "The Structural Genomics Consortium (SGC) is a not-for-profit organisation encompassing three sites: Universities of Oxford, Toronto and the Karolinska Institute, Stockholm. The SGC’s main goals are the structure determination of proteins ofmedical interest and dissemination of structural data to the public domain without restrictions. The UK site focuses on three main target areas: human dehydrogenases-reductases, membrane receptor and phosphorylation dependent signalling. Last year the SGC contributed about one fifth of all novel human structures deposited in the PDB with a current submission rate of 6-8 structures per month from theOxford site. Beyond the primary goal of increasing the number of available human protein structures, significant effort is being made to establish an infrastructure that supports the understanding of their mechanism and role in human diseases. This involves further steps from identification of potential ligands and inhibitors to determination of ligand complex structures. The structure determination pipeline of human proteins will be outlined using the human kinases solved at the Oxford site as an example. Special aspects of this protein family will be discussed with strong emphasis on structural and crystallographic questions. Challenges in crystallisation, such as stability and crystallisability as a function of ligand binding and phosphorylation, and subsequent structure solution and refinement will be illustrated by specific examples. m04.o01" @default.
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- W2022367208 date "2006-08-06" @default.
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- W2022367208 title "Structural genomics on human kinases at SGC Oxford" @default.
- W2022367208 doi "https://doi.org/10.1107/s0108767306099685" @default.
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