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- W2022367418 abstract "Abstract To explore the role of endogenous retroviruses in radiation-induced leukemogenesis in the mouse, we have examined virus-encoded proteins in nine BALB/c leukemias by pulse-chase labeling procedures and serological typing with monospecific and monoclonal antibodies. The major gag precursor protein, Pr65 gag , was observed in all cases, but only three leukemias expressed detectable amounts of the glycosylated gag species, gP95 gag , or its precursor, Pr75 gag . No evidence was found for synthesis of gag -host fusion proteins. None of the leukemias released infectious xenotropic or dualtropic virus, but all nine expressed at least one env protein with xenotropic properties. In two instances a monoclonal antibody, 35 56 , which is specific for the MuLV G IX antigen, displayed a distinctive reactivity with this class of env protein, although this antibody is unreactive with replicating xenotropic viruses. An ecotropic/xenotropic recombinant env protein with the same 35 56 phenotype was observed in a leukemia induced by a strongly leukemogenic virus isolated from a BALB/c radiation leukemia." @default.
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- W2022367418 date "1982-02-01" @default.
- W2022367418 modified "2023-09-25" @default.
- W2022367418 title "Endogenous murine leukemia virus-encoded proteins in radiation leukemias of BALB/c mice" @default.
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- W2022367418 doi "https://doi.org/10.1016/0042-6822(82)90520-7" @default.
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