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- W2022368785 abstract "Down-regulation of 5-hydroxytryptamine2A (5-HT2A) receptors has been a consistent effect induced by most antidepressant drugs. In contrast, electroconvulsive shock (ECS) up-regulates the number of 5-HT2A receptor binding sites. However, the effects of antidepressants on 5-HT2A receptor-mediated responses on identified cells of the cerebral cortex have not been examined. The purpose of the present study was to compare the effects of the tricyclic antidepressant imipramine and ECS on 5-HT2A receptor-mediated electrophysiological responses involving glutamatergic and GABAergic neurotransmission in the rat medial prefrontal cortex (mPFC) and piriform cortex, respectively. The electrophysiological effects of activating 5-HT2A receptors were consistent with 5-HT2A receptor binding regulation for imipramine and ECS except for the mPFC where chronic ECS decreased the potency of 5-HT at a 5-HT2A receptor-mediated response. These findings are consistent with the general hypothesis that chronic antidepressant treatments shift the balance of serotonergic neurotransmission towards inhibitory effects in the cortex." @default.
- W2022368785 created "2016-06-24" @default.
- W2022368785 creator A5004332028 @default.
- W2022368785 date "2008-07-01" @default.
- W2022368785 modified "2023-10-14" @default.
- W2022368785 title "Regulation of rat cortical 5-hydroxytryptamine2A receptor-mediated electrophysiological responses by repeated daily treatment with electroconvulsive shock or imipramine" @default.
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- W2022368785 doi "https://doi.org/10.1016/j.euroneuro.2008.01.003" @default.
- W2022368785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2453314" @default.
- W2022368785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18294819" @default.
- W2022368785 hasPublicationYear "2008" @default.
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