FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022369561> ?p ?o ?g. }

• W2022369561 endingPage "152" @default.
• W2022369561 startingPage "144" @default.
• W2022369561 abstract "The synthesis of a multiantigenic peptide dendrimer incorporating four copies of a cyclic disulfide epitope has been undertaken. Since standard chemoselective ligation procedures involving thioether formation are inadvisable in the presence of a preformed disulfide, conjugation through a peptide bond between the lipidated branched lysine scaffold and a suitably protected version of the cyclic disulfide has been used instead. Several synthetic approaches to the partially protected cyclic disulfide peptide have been explored. The most effective involves building a minimally protected version of the peptide by Boc solid phase synthesis, using fluorenyl-based anchorings and cysteine protecting groups. Peptide-resin cleavage and cysteine deprotection/oxidation are performed simultaneously by base-promoted elimination. The cyclic disulfide epitope is readily obtained in sufficient amounts by this procedure and subsequently incorporated to the lipidated lysine core by peptide bond formation in solution. A final acid deprotection step in anhydrous HF yields a peptide construction containing a maximum of three copies of the cyclic disulfide epitope, the lower substitution being attributable to steric constraints. This immunogen has been successfully used in an experimental vaccination trial against foot-and-mouth disease virus." @default.
• W2022369561 created "2016-06-24" @default.
• W2022369561 creator A5005646080 @default.
• W2022369561 creator A5019713653 @default.
• W2022369561 creator A5035036174 @default.
• W2022369561 creator A5091216330 @default.
• W2022369561 date "2002-12-04" @default.
• W2022369561 modified "2023-09-24" @default.
• W2022369561 title "Synthetic Approaches to Multivalent Lipopeptide Dendrimers Containing Cyclic Disulfide Epitopes of Foot-and-Mouth Disease Virus" @default.
• W2022369561 cites W1814313635 @default.
• W2022369561 cites W1984026060 @default.
• W2022369561 cites W1987602232 @default.
• W2022369561 cites W1997210540 @default.
• W2022369561 cites W2000045367 @default.
• W2022369561 cites W2010954863 @default.
• W2022369561 cites W2032022486 @default.
• W2022369561 cites W2032819946 @default.
• W2022369561 cites W2040764971 @default.
• W2022369561 cites W2041763155 @default.
• W2022369561 cites W2074153666 @default.
• W2022369561 cites W2087161023 @default.
• W2022369561 cites W2094243088 @default.
• W2022369561 cites W2163115454 @default.
• W2022369561 cites W2952810714 @default.
• W2022369561 doi "https://doi.org/10.1021/bc025577f" @default.
• W2022369561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12526703" @default.
• W2022369561 hasPublicationYear "2002" @default.
• W2022369561 type Work @default.
• W2022369561 sameAs 2022369561 @default.
• W2022369561 citedByCount "33" @default.
• W2022369561 countsByYear W20223695612012 @default.
• W2022369561 countsByYear W20223695612013 @default.
• W2022369561 countsByYear W20223695612014 @default.
• W2022369561 countsByYear W20223695612015 @default.
• W2022369561 countsByYear W20223695612016 @default.
• W2022369561 countsByYear W20223695612017 @default.
• W2022369561 countsByYear W20223695612018 @default.
• W2022369561 countsByYear W20223695612019 @default.
• W2022369561 countsByYear W20223695612021 @default.
• W2022369561 countsByYear W20223695612022 @default.
• W2022369561 crossrefType "journal-article" @default.
• W2022369561 hasAuthorship W2022369561A5005646080 @default.
• W2022369561 hasAuthorship W2022369561A5019713653 @default.
• W2022369561 hasAuthorship W2022369561A5035036174 @default.
• W2022369561 hasAuthorship W2022369561A5091216330 @default.
• W2022369561 hasConcept C159047783 @default.
• W2022369561 hasConcept C159654299 @default.
• W2022369561 hasConcept C167392928 @default.
• W2022369561 hasConcept C181199279 @default.
• W2022369561 hasConcept C185592680 @default.
• W2022369561 hasConcept C195616568 @default.
• W2022369561 hasConcept C203014093 @default.
• W2022369561 hasConcept C21951064 @default.
• W2022369561 hasConcept C2522874641 @default.
• W2022369561 hasConcept C2776151397 @default.
• W2022369561 hasConcept C2776469878 @default.
• W2022369561 hasConcept C2779201268 @default.
• W2022369561 hasConcept C2779281246 @default.
• W2022369561 hasConcept C2779809887 @default.
• W2022369561 hasConcept C2779909307 @default.
• W2022369561 hasConcept C542903549 @default.
• W2022369561 hasConcept C55493867 @default.
• W2022369561 hasConcept C55637122 @default.
• W2022369561 hasConcept C60984968 @default.
• W2022369561 hasConcept C71240020 @default.
• W2022369561 hasConcept C86803240 @default.
• W2022369561 hasConceptScore W2022369561C159047783 @default.
• W2022369561 hasConceptScore W2022369561C159654299 @default.
• W2022369561 hasConceptScore W2022369561C167392928 @default.
• W2022369561 hasConceptScore W2022369561C181199279 @default.
• W2022369561 hasConceptScore W2022369561C185592680 @default.
• W2022369561 hasConceptScore W2022369561C195616568 @default.
• W2022369561 hasConceptScore W2022369561C203014093 @default.
• W2022369561 hasConceptScore W2022369561C21951064 @default.
• W2022369561 hasConceptScore W2022369561C2522874641 @default.
• W2022369561 hasConceptScore W2022369561C2776151397 @default.
• W2022369561 hasConceptScore W2022369561C2776469878 @default.
• W2022369561 hasConceptScore W2022369561C2779201268 @default.
• W2022369561 hasConceptScore W2022369561C2779281246 @default.
• W2022369561 hasConceptScore W2022369561C2779809887 @default.
• W2022369561 hasConceptScore W2022369561C2779909307 @default.
• W2022369561 hasConceptScore W2022369561C542903549 @default.
• W2022369561 hasConceptScore W2022369561C55493867 @default.
• W2022369561 hasConceptScore W2022369561C55637122 @default.
• W2022369561 hasConceptScore W2022369561C60984968 @default.
• W2022369561 hasConceptScore W2022369561C71240020 @default.
• W2022369561 hasConceptScore W2022369561C86803240 @default.
• W2022369561 hasIssue "1" @default.
• W2022369561 hasLocation W20223695611 @default.
• W2022369561 hasLocation W20223695612 @default.
• W2022369561 hasOpenAccess W2022369561 @default.
• W2022369561 hasPrimaryLocation W20223695611 @default.
• W2022369561 hasRelatedWork W1983233853 @default.
• W2022369561 hasRelatedWork W1989479815 @default.
• W2022369561 hasRelatedWork W2015347477 @default.
• W2022369561 hasRelatedWork W2022369561 @default.
• W2022369561 hasRelatedWork W2153043341 @default.
• W2022369561 hasRelatedWork W2325079584 @default.

• next