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- W2022370315 abstract "In liver and kidney microsomes of male control and barbital-treated Wistar rats aged 10, 18, 33, 63 and 123 days the content of cytochromes P-450 and b5 and the activity of glucose-6-phosphatase have been studied. The cytochrome P-450 content of the liver increases slightly during the first 4 weeks of life. Barbital enhances the amount of cytochrome P-450 in all age groups but in 10-day-old rats the induction was very poor. The changes of cytochrome P-450 due to ageing and to barbital are not correlated with changes in the various drug-metabolizing reactions. It is concluded that the amount of cytochrorne P-450 is not the rate-limiting factor in drug oxidation. In connection with former investigations more than one monoxygenase system or cytochrome P-450 are assumed. The cytochrome b5 amount decreases slightly during ageing and was not influenced by barbital. The activity of glucose-6-phosphatase was greatest in young rats and then declined with increasing age. Barbital treatment does not change the activity." @default.
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- W2022370315 date "1973-04-01" @default.
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- W2022370315 title "The influence of age and barbital treatment on the content of cytochrome P-450 and b5 and on the activity of glucose-6-phosphatase in microsomes of the rat liver and kidney" @default.
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- W2022370315 doi "https://doi.org/10.1016/0006-2952(73)90214-1" @default.
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