FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022370560> ?p ?o ?g. }

• W2022370560 endingPage "708" @default.
• W2022370560 startingPage "699" @default.
• W2022370560 abstract "Phosphorus-31 magnetic resonance (31P MR) spectroscopy was used to obtain serial in vivo measurements of cerebral adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi), and intracellular pH levels in rats during temporary global cerebral ischemia and reperfusion. Three groups of 4 rats each that recovered from permanent bilateral vertebral artery occlusion were placed in a MR spectrometer and subjected to remotely controlled bilateral carotid artery occlusion lasting 6, 15, or 30 minutes followed by 1 hour of reperfusion. Four additional rats that developed systemic hypotension (2 during a 6-minute occlusion and 2 during a 15-minute occlusion) were also studied. 31P MR spectra were obtained in each rat before, during, and after ischemia. Rats in which MR spectra showed metabolic recovery underwent a second occlusion followed by reperfusion and sacrifice. In the 12 normotensive rats, metabolic alterations began within 3 minutes after the onset of global ischemia. By the end of the occlusion period, cerebral ATP had decreased by 20 to 100% in 10 rats and PCr had decreased by 15 to 75% in all 12; Pi increased by 25 to 240%. The mean intracellular pH decreased from 7.33 to 6.9 +/- 0.6. The degree of metabolic deterioration during ischemia was not related to the duration of occlusion. During reperfusion, ATP, PCr, Pi, and intracellular pH returned to normal in 4 rats; 5 rats had partial metabolic recovery, and 3 had minimal or transient metabolic recovery followed by progressive deterioration. All rats that developed systemic hypotension had a decrease in ATP, PCr, and intracellular pH and an increase in Pi during the initial occlusion. Each had transient partial recovery in ATP during reperfusion, and 2 had slight recovery of PCr. The onset of hypotension was followed by depletion of these metabolites, progressive increase in Pi, and progressive intracellular acidosis. All rats that deteriorated metabolically after reversal of carotid occlusion died by the end of the reperfusion period or soon after. The 8 rats that recovered from the first occlusion were subjected to a second period of ischemia, during which each rat showed severe depletion of metabolites. During the second reperfusion, only 1 rat showed significant metabolic recovery, which lasted only 30 minutes and was followed by progressive deterioration. Severe global cerebral ischemia was associated with a progressive decline in both ATP and PCr, whereas less complete ischemia seemed to be characterized by stabilization or recovery of ATP and continued depression of PCr.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2022370560 created "2016-06-24" @default.
• W2022370560 creator A5002418169 @default.
• W2022370560 creator A5005008732 @default.
• W2022370560 creator A5008288127 @default.
• W2022370560 creator A5076261158 @default.
• W2022370560 date "1987-11-01" @default.
• W2022370560 modified "2023-09-25" @default.
• W2022370560 title "Sequential in Vivo Measurement of Cerebral Intracellular Metabolites with Phosphorus-31 Magnetic Resonance Spectroscopy during Global Cerebral Ischemia and Reperfusion in Rats" @default.
• W2022370560 doi "https://doi.org/10.1227/00006123-198711000-00017" @default.
• W2022370560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3696405" @default.
• W2022370560 hasPublicationYear "1987" @default.
• W2022370560 type Work @default.
• W2022370560 sameAs 2022370560 @default.
• W2022370560 citedByCount "23" @default.
• W2022370560 crossrefType "journal-article" @default.
• W2022370560 hasAuthorship W2022370560A5002418169 @default.
• W2022370560 hasAuthorship W2022370560A5005008732 @default.
• W2022370560 hasAuthorship W2022370560A5008288127 @default.
• W2022370560 hasAuthorship W2022370560A5076261158 @default.
• W2022370560 hasConcept C126322002 @default.
• W2022370560 hasConcept C134018914 @default.
• W2022370560 hasConcept C134897140 @default.
• W2022370560 hasConcept C150903083 @default.
• W2022370560 hasConcept C185592680 @default.
• W2022370560 hasConcept C207001950 @default.
• W2022370560 hasConcept C2776268601 @default.
• W2022370560 hasConcept C2778626300 @default.
• W2022370560 hasConcept C2986317502 @default.
• W2022370560 hasConcept C42219234 @default.
• W2022370560 hasConcept C541997718 @default.
• W2022370560 hasConcept C55493867 @default.
• W2022370560 hasConcept C71924100 @default.
• W2022370560 hasConcept C79879829 @default.
• W2022370560 hasConcept C86803240 @default.
• W2022370560 hasConceptScore W2022370560C126322002 @default.
• W2022370560 hasConceptScore W2022370560C134018914 @default.
• W2022370560 hasConceptScore W2022370560C134897140 @default.
• W2022370560 hasConceptScore W2022370560C150903083 @default.
• W2022370560 hasConceptScore W2022370560C185592680 @default.
• W2022370560 hasConceptScore W2022370560C207001950 @default.
• W2022370560 hasConceptScore W2022370560C2776268601 @default.
• W2022370560 hasConceptScore W2022370560C2778626300 @default.
• W2022370560 hasConceptScore W2022370560C2986317502 @default.
• W2022370560 hasConceptScore W2022370560C42219234 @default.
• W2022370560 hasConceptScore W2022370560C541997718 @default.
• W2022370560 hasConceptScore W2022370560C55493867 @default.
• W2022370560 hasConceptScore W2022370560C71924100 @default.
• W2022370560 hasConceptScore W2022370560C79879829 @default.
• W2022370560 hasConceptScore W2022370560C86803240 @default.
• W2022370560 hasIssue "5" @default.
• W2022370560 hasLocation W20223705601 @default.
• W2022370560 hasLocation W20223705602 @default.
• W2022370560 hasOpenAccess W2022370560 @default.
• W2022370560 hasPrimaryLocation W20223705601 @default.
• W2022370560 hasRelatedWork W1988513890 @default.
• W2022370560 hasRelatedWork W2005360030 @default.
• W2022370560 hasRelatedWork W2022370560 @default.
• W2022370560 hasRelatedWork W2067202040 @default.
• W2022370560 hasRelatedWork W2077288842 @default.
• W2022370560 hasRelatedWork W2116160593 @default.
• W2022370560 hasRelatedWork W2121416425 @default.
• W2022370560 hasRelatedWork W2153298820 @default.
• W2022370560 hasRelatedWork W2406271451 @default.
• W2022370560 hasRelatedWork W4238111011 @default.
• W2022370560 hasVolume "21" @default.
• W2022370560 isParatext "false" @default.
• W2022370560 isRetracted "false" @default.
• W2022370560 magId "2022370560" @default.
• W2022370560 workType "article" @default.