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- W2022372459 abstract "The ACh hydrolyzing enzyme acetylcholinesterase (AChE) is a combinatorial series of proteins with variant N and C termini generated from alternate promoter usage and 3' alternative splicing. Neuronal AChE variants show indistinguishable enzymatic activity yet differ in their expression, multimeric assembly and membrane-association patterns. Differentially induced under stress, they show distinct non-hydrolytic properties and interact with different protein partners. Recent findings suggest that transcriptional and post-transcriptional regulation of AChE pre-mRNA is a neuroprotection strategy but might involve long-term damage. Specifically, variant-specific causal involvement of AChE in the progression of both neurodegenerative diseases (e.g. Alzheimer's and Parkinson's diseases) and neuromuscular syndromes (e.g. myasthenia gravis) raises the possibility that future therapeutic drugs might target specific AChE variant(s) or the corresponding RNA transcripts." @default.
- W2022372459 created "2016-06-24" @default.
- W2022372459 creator A5003680413 @default.
- W2022372459 creator A5034050775 @default.
- W2022372459 date "2006-04-01" @default.
- W2022372459 modified "2023-10-16" @default.
- W2022372459 title "Virtues and woes of AChE alternative splicing in stress-related neuropathologies" @default.
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- W2022372459 cites W1549536215 @default.
- W2022372459 cites W1555873394 @default.
- W2022372459 cites W1562398969 @default.
- W2022372459 cites W1568968913 @default.
- W2022372459 cites W1660120640 @default.
- W2022372459 cites W1707125763 @default.
- W2022372459 cites W1968001587 @default.
- W2022372459 cites W1970767854 @default.
- W2022372459 cites W1971711780 @default.
- W2022372459 cites W1976919405 @default.
- W2022372459 cites W1978598728 @default.
- W2022372459 cites W1978995691 @default.
- W2022372459 cites W1981321743 @default.
- W2022372459 cites W1985900925 @default.
- W2022372459 cites W1990351437 @default.
- W2022372459 cites W1999487380 @default.
- W2022372459 cites W2000565404 @default.
- W2022372459 cites W2003060921 @default.
- W2022372459 cites W2005657046 @default.
- W2022372459 cites W2006814415 @default.
- W2022372459 cites W2013132270 @default.
- W2022372459 cites W2016148530 @default.
- W2022372459 cites W2016698723 @default.
- W2022372459 cites W2018885303 @default.
- W2022372459 cites W2019105280 @default.
- W2022372459 cites W2024289681 @default.
- W2022372459 cites W2036167046 @default.
- W2022372459 cites W2037359287 @default.
- W2022372459 cites W2042239339 @default.
- W2022372459 cites W2046467776 @default.
- W2022372459 cites W2046917404 @default.
- W2022372459 cites W2048625504 @default.
- W2022372459 cites W2051679721 @default.
- W2022372459 cites W2055602100 @default.
- W2022372459 cites W2057817087 @default.
- W2022372459 cites W2058088248 @default.
- W2022372459 cites W2059820056 @default.
- W2022372459 cites W2066347364 @default.
- W2022372459 cites W2068921529 @default.
- W2022372459 cites W2072219894 @default.
- W2022372459 cites W2072914101 @default.
- W2022372459 cites W2074855098 @default.
- W2022372459 cites W2082638576 @default.
- W2022372459 cites W2084107396 @default.
- W2022372459 cites W2087125515 @default.
- W2022372459 cites W2089157424 @default.
- W2022372459 cites W2092765984 @default.
- W2022372459 cites W2095997832 @default.
- W2022372459 cites W2101558054 @default.
- W2022372459 cites W2102615381 @default.
- W2022372459 cites W2104580322 @default.
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- W2022372459 cites W2112638355 @default.
- W2022372459 cites W2116424844 @default.
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- W2022372459 cites W2120361033 @default.
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- W2022372459 cites W2128129890 @default.
- W2022372459 cites W2134236497 @default.
- W2022372459 cites W2135890562 @default.
- W2022372459 cites W2137809729 @default.
- W2022372459 cites W2137824309 @default.
- W2022372459 cites W2139402373 @default.
- W2022372459 cites W2141926052 @default.
- W2022372459 cites W2145669366 @default.
- W2022372459 cites W2158386063 @default.
- W2022372459 cites W2159998873 @default.
- W2022372459 cites W2160561007 @default.
- W2022372459 cites W2165828523 @default.
- W2022372459 cites W2169260018 @default.
- W2022372459 cites W4235860870 @default.
- W2022372459 doi "https://doi.org/10.1016/j.tins.2006.02.005" @default.
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