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- W2022372488 abstract "ABSTRACT A population pharmacokinetic model of telavancin, a lipoglycopeptide antibiotic, was developed and used to identify sources of interindividual variability. Data were obtained from healthy subjects (seven phase 1 studies), patients with complicated skin and skin structure infections (cSSSI; two phase 2 and two phase 3 studies), and patients with hospital-acquired pneumonia (HAP; two phase 3 studies). A two-compartment open model with zero-order input best fit the telavancin data from healthy individuals and patients with cSSSI or HAP. Telavancin clearance was highly correlated with renal function and, to a lesser extent, with body weight. Other covariates were related to at least one parameter in cSSSI (gender, bacterial eradication, and surgery) or HAP (age of ≥75 years) but did not markedly affect exposure. These analyses support current dosing recommendations for telavancin based on patient weight and renal function." @default.
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- W2022372488 date "2012-04-01" @default.
- W2022372488 modified "2023-09-23" @default.
- W2022372488 title "Population Pharmacokinetics of Telavancin in Healthy Subjects and Patients with Infections" @default.
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- W2022372488 doi "https://doi.org/10.1128/aac.05915-11" @default.
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