Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022372975> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2022372975 endingPage "883" @default.
- W2022372975 startingPage "879" @default.
- W2022372975 abstract "This study was designed to determine the effects of dexmedetomidine on perioperative myocardial injury by observing peripheral circulatory changes in response to tracheal intubation and extubation, myocardial enzyme levels, myocardial ischaemia improvements, cardiovascular adverse events and cytokines in patients with coronary heart disease (CHD) undergoing non-cardiac surgery. This study was a prospective, randomized, double-blind trial. Eighty patients having CHD were scheduled for elective hip-replacement surgery and randomly allocated to receive a loading dose of 1 μg/kg dexmedetomidine followed by a 0.2 μg/kg per h infusion (Dex group; n = 40) or normal saline (control group; n = 40). Systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, rate–pressure product and changes in ST-T segment on the electrocardiogram were recorded every 5 min during surgery. Serum creatine kinase-MB (CK-MB), cardiac troponin I (cTnI), glycogen phosphorylase BB (GP-BB), interleukin (IL)-6 and tumour necrosis factor (TNF)-α protein levels were determined preoperatively, at the end of surgery and 12 and 24 h after surgery. The improvement rate of myocardial ischaemia was higher in the Dex than control group (87.5% vs 32.5%, respectively; P < 0.05). In addition, the Dex group had lower serum CK-MB, IL-6, cTnI and GP-BB concentrations than the control group (P < 0.05). There was no significance difference in TNF-α between the two groups (P > 0.05). Dexmedetomidine can reduce myocardial injury and cytokine levels in patients with CHD undergoing non-cardiac surgery." @default.
- W2022372975 created "2016-06-24" @default.
- W2022372975 creator A5000030352 @default.
- W2022372975 creator A5027044461 @default.
- W2022372975 creator A5045291216 @default.
- W2022372975 creator A5081038204 @default.
- W2022372975 date "2014-11-01" @default.
- W2022372975 modified "2023-10-14" @default.
- W2022372975 title "Does dexmedetomidine have a cardiac protective effect during non-cardiac surgery? A randomised controlled trial" @default.
- W2022372975 cites W2001986050 @default.
- W2022372975 cites W2004975905 @default.
- W2022372975 cites W2013889019 @default.
- W2022372975 cites W2016403632 @default.
- W2022372975 cites W2039625304 @default.
- W2022372975 cites W2041543528 @default.
- W2022372975 cites W2042612584 @default.
- W2022372975 cites W2055220033 @default.
- W2022372975 cites W2074602210 @default.
- W2022372975 cites W2084914605 @default.
- W2022372975 cites W2092128754 @default.
- W2022372975 cites W2103817224 @default.
- W2022372975 cites W2109201402 @default.
- W2022372975 cites W2142590667 @default.
- W2022372975 cites W2148491638 @default.
- W2022372975 cites W2149783299 @default.
- W2022372975 cites W2163300164 @default.
- W2022372975 cites W3215088586 @default.
- W2022372975 doi "https://doi.org/10.1111/1440-1681.12296" @default.
- W2022372975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25132247" @default.
- W2022372975 hasPublicationYear "2014" @default.
- W2022372975 type Work @default.
- W2022372975 sameAs 2022372975 @default.
- W2022372975 citedByCount "13" @default.
- W2022372975 countsByYear W20223729752015 @default.
- W2022372975 countsByYear W20223729752016 @default.
- W2022372975 countsByYear W20223729752017 @default.
- W2022372975 countsByYear W20223729752018 @default.
- W2022372975 countsByYear W20223729752019 @default.
- W2022372975 countsByYear W20223729752020 @default.
- W2022372975 countsByYear W20223729752021 @default.
- W2022372975 crossrefType "journal-article" @default.
- W2022372975 hasAuthorship W2022372975A5000030352 @default.
- W2022372975 hasAuthorship W2022372975A5027044461 @default.
- W2022372975 hasAuthorship W2022372975A5045291216 @default.
- W2022372975 hasAuthorship W2022372975A5081038204 @default.
- W2022372975 hasConcept C115725540 @default.
- W2022372975 hasConcept C126322002 @default.
- W2022372975 hasConcept C164705383 @default.
- W2022372975 hasConcept C2776452961 @default.
- W2022372975 hasConcept C2776814716 @default.
- W2022372975 hasConcept C2777953023 @default.
- W2022372975 hasConcept C2778789114 @default.
- W2022372975 hasConcept C2781302539 @default.
- W2022372975 hasConcept C31174226 @default.
- W2022372975 hasConcept C36880943 @default.
- W2022372975 hasConcept C42219234 @default.
- W2022372975 hasConcept C500558357 @default.
- W2022372975 hasConcept C71316499 @default.
- W2022372975 hasConcept C71924100 @default.
- W2022372975 hasConcept C84393581 @default.
- W2022372975 hasConceptScore W2022372975C115725540 @default.
- W2022372975 hasConceptScore W2022372975C126322002 @default.
- W2022372975 hasConceptScore W2022372975C164705383 @default.
- W2022372975 hasConceptScore W2022372975C2776452961 @default.
- W2022372975 hasConceptScore W2022372975C2776814716 @default.
- W2022372975 hasConceptScore W2022372975C2777953023 @default.
- W2022372975 hasConceptScore W2022372975C2778789114 @default.
- W2022372975 hasConceptScore W2022372975C2781302539 @default.
- W2022372975 hasConceptScore W2022372975C31174226 @default.
- W2022372975 hasConceptScore W2022372975C36880943 @default.
- W2022372975 hasConceptScore W2022372975C42219234 @default.
- W2022372975 hasConceptScore W2022372975C500558357 @default.
- W2022372975 hasConceptScore W2022372975C71316499 @default.
- W2022372975 hasConceptScore W2022372975C71924100 @default.
- W2022372975 hasConceptScore W2022372975C84393581 @default.
- W2022372975 hasIssue "11" @default.
- W2022372975 hasLocation W20223729751 @default.
- W2022372975 hasLocation W20223729752 @default.
- W2022372975 hasOpenAccess W2022372975 @default.
- W2022372975 hasPrimaryLocation W20223729751 @default.
- W2022372975 hasRelatedWork W2349812049 @default.
- W2022372975 hasRelatedWork W2556028119 @default.
- W2022372975 hasRelatedWork W2618310508 @default.
- W2022372975 hasRelatedWork W2949154913 @default.
- W2022372975 hasRelatedWork W3047396637 @default.
- W2022372975 hasRelatedWork W3158507702 @default.
- W2022372975 hasRelatedWork W3176363181 @default.
- W2022372975 hasRelatedWork W3201244965 @default.
- W2022372975 hasRelatedWork W2900543300 @default.
- W2022372975 hasRelatedWork W3082641231 @default.
- W2022372975 hasVolume "41" @default.
- W2022372975 isParatext "false" @default.
- W2022372975 isRetracted "false" @default.
- W2022372975 magId "2022372975" @default.
- W2022372975 workType "article" @default.