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- W2022374964 abstract "The excretion of radioactivity from radiolabeled endrin and dieldrin, chlorinated hydrocarbon insecticide stereoisomers, has been compared in whole rats, bile-fistula rats, and isolated perfused rat livers. Male Holtzman rats, with and without bile fistulas were given intravenous doses (0.25 mg/kg) of endrin-14C or dieldrin-14C. Urine and feces were collected daily. Bile was collected at 1, 3, 6, 12, and 24 hours and daily thereafter. The animals were maintained for 5–7 days, then were sacrificed. Isolated, perfused rat liver experiments were performed with radiolabeled insecticides in the perfusates (0.003 or 0.0003 mg/ml). Bile and perfusate were sampled hourly. The liver was sampled at the end of the 4–6-hour experiment. Radioactivity in all excreta, carcasses, bile, perfusates, and liver tissue was measured by liquid scintillation counting. Over 90% of the excreted activity was found in the feces of the intact animals and in the bile of fistula animals. The cumulative mean daily excretion of radioactivity from endrin was greater than that from dieldrin in the feces of intact animals, bile of bile-fistula animals, and bile of isolated, perfused rat liver preparations. The more rapid fecal elimination of endrin can be explained by its more rapid biliary excretion. Intestinal absorption and fatty tissue sequestration have been excluded as major factors, and the liver has been identified as the source of the difference. These results may explain the greater storage of dieldrin in the body fat of mammals." @default.
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- W2022374964 title "Endrin and dieldrin: A comparison of hepatic excretion in the rat" @default.
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- W2022374964 doi "https://doi.org/10.1016/0041-008x(70)90030-x" @default.
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