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- W2022375853 abstract "The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and transduced by various intracellular signal pathways is modulated by the IGF Binding Proteins (IGFBPs). Among all the IGFBPs, IGFBP-2 has been implicated in the regulation of IGF activity in most tissue and organs. Besides binding to IGFs in the circulation these IGF-regulatory activities of IGFBP-2 involve interactions with components of the extracellular matrix, cell surface proteoglycans and integrin receptors. In addition to these local peri-cellular activities, IGFBP-2 exerts other key functions within the nucleus, where IGFBP-2 directly or indirectly promotes transcriptional activation of specific genes. All of these IGFBP-2 activities, intrinsic or dependent on IGFs, contribute to its functional roles in growth/development, metabolism and malignancy as evidenced by studies in IGFBP-2 animal models and also by many in vitro studies. Finally, preclinical studies have demonstrated that IGFBP-2 administration can be beneficial in improving metabolic responses (inhibition of adipogenesis and enhanced insulin sensitivity), while blockade of IGFBP-2 appears to be an effective approach to inhibiting tumour growth and metastasis." @default.
- W2022375853 created "2016-06-24" @default.
- W2022375853 creator A5016518307 @default.
- W2022375853 creator A5060767771 @default.
- W2022375853 creator A5072238018 @default.
- W2022375853 creator A5072393526 @default.
- W2022375853 creator A5079075142 @default.
- W2022375853 date "2015-01-25" @default.
- W2022375853 modified "2023-10-16" @default.
- W2022375853 title "IGFBP-2 - taking the lead in growth, metabolism and cancer" @default.
- W2022375853 cites W12390649 @default.
- W2022375853 cites W127913739 @default.
- W2022375853 cites W144666311 @default.
- W2022375853 cites W1483108553 @default.
- W2022375853 cites W1491177143 @default.
- W2022375853 cites W1493048246 @default.
- W2022375853 cites W1504464280 @default.
- W2022375853 cites W1585635925 @default.
- W2022375853 cites W1631449371 @default.
- W2022375853 cites W1904552623 @default.
- W2022375853 cites W1940619648 @default.
- W2022375853 cites W1964285047 @default.
- W2022375853 cites W1964614824 @default.
- W2022375853 cites W1966927919 @default.
- W2022375853 cites W1970142642 @default.
- W2022375853 cites W1970978923 @default.
- W2022375853 cites W1971145635 @default.
- W2022375853 cites W1971301417 @default.
- W2022375853 cites W1974086084 @default.
- W2022375853 cites W1974379520 @default.
- W2022375853 cites W1976130423 @default.
- W2022375853 cites W1978126914 @default.
- W2022375853 cites W1978667886 @default.
- W2022375853 cites W1980591059 @default.
- W2022375853 cites W1980601284 @default.
- W2022375853 cites W1982485018 @default.
- W2022375853 cites W1982836278 @default.
- W2022375853 cites W1983230888 @default.
- W2022375853 cites W1983538600 @default.
- W2022375853 cites W1983807922 @default.
- W2022375853 cites W1986734640 @default.
- W2022375853 cites W1987290581 @default.
- W2022375853 cites W1987775895 @default.
- W2022375853 cites W1988656729 @default.
- W2022375853 cites W1988992304 @default.
- W2022375853 cites W1989017986 @default.
- W2022375853 cites W1990176822 @default.
- W2022375853 cites W1991011471 @default.
- W2022375853 cites W1992275613 @default.
- W2022375853 cites W1995778724 @default.
- W2022375853 cites W1996749397 @default.
- W2022375853 cites W1997013213 @default.
- W2022375853 cites W2000622771 @default.
- W2022375853 cites W2001295103 @default.
- W2022375853 cites W2002698510 @default.
- W2022375853 cites W2005723048 @default.
- W2022375853 cites W2006969357 @default.
- W2022375853 cites W2008790407 @default.
- W2022375853 cites W2009093593 @default.
- W2022375853 cites W2009412110 @default.
- W2022375853 cites W2010927862 @default.
- W2022375853 cites W2011264397 @default.
- W2022375853 cites W2011810742 @default.
- W2022375853 cites W2012505775 @default.
- W2022375853 cites W2012818711 @default.
- W2022375853 cites W2012941743 @default.
- W2022375853 cites W2013817786 @default.
- W2022375853 cites W2014219735 @default.
- W2022375853 cites W2015570910 @default.
- W2022375853 cites W2015614584 @default.
- W2022375853 cites W2016189250 @default.
- W2022375853 cites W2016493686 @default.
- W2022375853 cites W2018690794 @default.
- W2022375853 cites W2021868940 @default.
- W2022375853 cites W2022214646 @default.
- W2022375853 cites W2022275682 @default.
- W2022375853 cites W2023021466 @default.
- W2022375853 cites W2024055311 @default.
- W2022375853 cites W2024528924 @default.
- W2022375853 cites W2025086558 @default.
- W2022375853 cites W2025853036 @default.
- W2022375853 cites W2026816311 @default.
- W2022375853 cites W2028080517 @default.
- W2022375853 cites W2028992928 @default.
- W2022375853 cites W2029295641 @default.
- W2022375853 cites W2030378687 @default.
- W2022375853 cites W2030550361 @default.
- W2022375853 cites W2031608734 @default.
- W2022375853 cites W2034259759 @default.
- W2022375853 cites W2037592578 @default.
- W2022375853 cites W2037610509 @default.
- W2022375853 cites W2039356709 @default.
- W2022375853 cites W2039756216 @default.
- W2022375853 cites W2040929551 @default.
- W2022375853 cites W2042752592 @default.
- W2022375853 cites W2043131574 @default.
- W2022375853 cites W2043863425 @default.
- W2022375853 cites W2044670939 @default.