FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022376314> ?p ?o ?g. }

• W2022376314 endingPage "862" @default.
• W2022376314 startingPage "804" @default.
• W2022376314 abstract "From 183 patients undergoing upper gastrointestinal endoscopy, we used antral and corpus gastric biopsies for bacterial culture and histopathologic examination, blood samples to detect immunoglobulin G antibodies against Helicobacter pylori, and H pylori genomic DNA to analyze cytotoxin-associated gene A (cagA) and vacuolating cytotoxin (vacA) genotypes. As expected, among H pylori biopsy-positive patients, those with duodenal ulcer (DU) (n = 34) had significantly more severe chronic and acute inflammation (P <.001) and epithelial degeneration (P =.004) in the gastric antrum than in the gastric corpus. Each of those 3 parameters and H pylori density were significantly higher in the antrum of patients with DU than in patients with gastric ulcer (GU) or no ulcer. Colonization with vacA s1/cagA-positive strains of H pylori was associated with inflammation and epithelial degeneration in gastric mucosa and increased risk for peptic ulcer disease (PUD), whereas colonization with vacA s2m2/cagA-negative strains was associated with mild gastric histopathology and was not associated with any significant risk for PUD. The predominant H pylori strains in African Americans were vacA s1bm1/cagA-positive, whereas all genotypes were well represented in non—Hispanic-Caucasians. By multivariate analysis, H pylori colonization was significantly associated with DU (Adjusted odds ratio [AdjOR] = 3.2 [1.4-7.2]) and nonsteroidal anti-inflammatory drugs (NSAID) use was inversely associated (AdjOR = 0.3 [0.2-0.7]). NSAID use (AdjOR = 4.3 [1.02-18.5]) and African-American ethnicity (AdjOR = 10.9 [2.6-50]) were significantly associated with GU. Smoking and age were not significantly associated with either DU or GU. These data indicate that DU is associated with an antral-dominant gastritis, and H pylori genotype and NSAID use independently contribute to the pathogenesis of PUD. HUM PATHOL 32:264-273. This is a US Government work. There are no restrictions on its use." @default.
• W2022376314 created "2016-06-24" @default.
• W2022376314 creator A5007423221 @default.
• W2022376314 creator A5065199181 @default.
• W2022376314 creator A5074640506 @default.
• W2022376314 date "2005-12-01" @default.
• W2022376314 modified "2023-09-26" @default.
• W2022376314 title "Helicobacter pylori Infection and Surgical Disease—Part II" @default.
• W2022376314 cites W120470527 @default.
• W2022376314 cites W1481836604 @default.
• W2022376314 cites W1501462558 @default.
• W2022376314 cites W1502138876 @default.
• W2022376314 cites W1511963303 @default.
• W2022376314 cites W1520492432 @default.
• W2022376314 cites W1550141031 @default.
• W2022376314 cites W1553985007 @default.
• W2022376314 cites W1570222491 @default.
• W2022376314 cites W158216511 @default.
• W2022376314 cites W1599164145 @default.
• W2022376314 cites W164051564 @default.
• W2022376314 cites W1715578537 @default.
• W2022376314 cites W1778763235 @default.
• W2022376314 cites W1877917243 @default.
• W2022376314 cites W1940581443 @default.
• W2022376314 cites W1958366167 @default.
• W2022376314 cites W1964021200 @default.
• W2022376314 cites W1964082374 @default.
• W2022376314 cites W1964190476 @default.
• W2022376314 cites W1965341361 @default.
• W2022376314 cites W1965653329 @default.
• W2022376314 cites W1966660119 @default.
• W2022376314 cites W1966799949 @default.
• W2022376314 cites W1966807139 @default.
• W2022376314 cites W1966925423 @default.
• W2022376314 cites W1968211961 @default.
• W2022376314 cites W1969049887 @default.
• W2022376314 cites W1970032501 @default.
• W2022376314 cites W1970107675 @default.
• W2022376314 cites W1974570006 @default.
• W2022376314 cites W1975676438 @default.
• W2022376314 cites W1978742257 @default.
• W2022376314 cites W1982206923 @default.
• W2022376314 cites W1983517028 @default.
• W2022376314 cites W1983972130 @default.
• W2022376314 cites W1985957492 @default.
• W2022376314 cites W1986474963 @default.
• W2022376314 cites W1986704757 @default.
• W2022376314 cites W1989107717 @default.
• W2022376314 cites W1991078449 @default.
• W2022376314 cites W1991444764 @default.
• W2022376314 cites W1992815258 @default.
• W2022376314 cites W1992945893 @default.
• W2022376314 cites W1994742518 @default.
• W2022376314 cites W1994871606 @default.
• W2022376314 cites W1995018598 @default.
• W2022376314 cites W1996405559 @default.
• W2022376314 cites W1999817367 @default.
• W2022376314 cites W2000868119 @default.
• W2022376314 cites W2001570428 @default.
• W2022376314 cites W2002075214 @default.
• W2022376314 cites W2003192378 @default.
• W2022376314 cites W2004502477 @default.
• W2022376314 cites W2004950762 @default.
• W2022376314 cites W2005670414 @default.
• W2022376314 cites W2008606069 @default.
• W2022376314 cites W2009039270 @default.
• W2022376314 cites W2009107334 @default.
• W2022376314 cites W2009803579 @default.
• W2022376314 cites W2010459522 @default.
• W2022376314 cites W2014836685 @default.
• W2022376314 cites W2015540325 @default.
• W2022376314 cites W2015819589 @default.
• W2022376314 cites W2015993853 @default.
• W2022376314 cites W2016351603 @default.
• W2022376314 cites W2016810740 @default.
• W2022376314 cites W2017433315 @default.
• W2022376314 cites W2017569060 @default.
• W2022376314 cites W2020144863 @default.
• W2022376314 cites W2022753621 @default.
• W2022376314 cites W2022861452 @default.
• W2022376314 cites W2023434926 @default.
• W2022376314 cites W2025326029 @default.
• W2022376314 cites W2025351789 @default.
• W2022376314 cites W2025700860 @default.
• W2022376314 cites W2026364039 @default.
• W2022376314 cites W2027113658 @default.
• W2022376314 cites W2028125597 @default.
• W2022376314 cites W2028598419 @default.
• W2022376314 cites W2030067914 @default.
• W2022376314 cites W2031009835 @default.
• W2022376314 cites W2034165112 @default.
• W2022376314 cites W2034468337 @default.
• W2022376314 cites W2034673009 @default.
• W2022376314 cites W2035439896 @default.
• W2022376314 cites W2035564279 @default.
• W2022376314 cites W2038426029 @default.
• W2022376314 cites W2041435471 @default.
• W2022376314 cites W2042602808 @default.

• next