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- W2022376469 abstract "Metabolic engineering technology for industrial microorganisms is under development to create rational, more reliable, and more cost-effective approaches to strain improvement. Strain improvement is a critical component of the drug development process, yet the genetic basis for high production by industrial microorganisms is still a mystery. In this study, a search was begun for genetic modifications critical for high-level antibiotic production. The model system used was erythromycin production studied in the unicellular actinomycete, Aeromicrobium erythreum. A tagged-mutagenesis approach allowed reverse engineering of improved strains, revealing two genes, mutB and cobA, in the primary metabolic branch for methylmalonyl-CoA utilization. Knockouts in these genes created a permanent metabolic switch in the flow of methylmalonyl-CoA, from the primary branch into a secondary metabolic branch, driving erythromycin overproduction. The model provides insights into the regulation and evolution of secondary metabolism." @default.
- W2022376469 created "2016-06-24" @default.
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- W2022376469 date "2004-10-01" @default.
- W2022376469 modified "2023-10-14" @default.
- W2022376469 title "Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum" @default.
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- W2022376469 doi "https://doi.org/10.1016/j.ymben.2004.03.003" @default.
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