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• W2022377785 abstract "Interferons regulate the expression of a large number of mammalian genes, including the major histocompatibility antigen genes. To investigate the mechanisms involved in interferon action, we have analyzed the ability of murine H-2Ld and H-2Dd DNA sequences to control the responses to interferon. The results indicate that interferon regulation of class I gene expression is complex and involves at least two mechanisms that are dependent on class I sequences located upstream and downstream to the transcription initiation site. In transfected mouse L cells, both of these regions are required for full enhancement of class I gene expression, with the major portion of the response controlled by the sequences located 3' to the transcription initiation site. The fine-mapping analysis of the 5' region-encoded response also suggests that recombinant alpha and gamma interferons may exert their effects on class I gene expression by using different cis-acting regulatory sequences." @default.
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• W2022377785 date "1987-05-01" @default.
• W2022377785 modified "2023-09-26" @default.
• W2022377785 title "Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site." @default.
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• W2022377785 doi "https://doi.org/10.1073/pnas.84.10.3380" @default.
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