Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022378420> ?p ?o ?g. }
- W2022378420 endingPage "3104" @default.
- W2022378420 startingPage "3096" @default.
- W2022378420 abstract "Inhibition of the excessive NO production has been recognized as a potential means for the treatment of rheumatoid arthritis (RA). In order to discover more potent inhibitors and explore the preliminary structure activity relationship, a series of unique stereodimers of sinomenine analogues were designed and synthesized. Their inhibitory activity on NO production and cytotoxicity were evaluated using LPS-activated murine macrophages RAW264.7 assay and MTT method, respectively. Among these compounds, 1a, 2, 2a, 2b, and 4 showed potent inhibitory activity on NO production without obvious cytotoxicity. Furthermore, 2, 2a, and 2b significantly suppressed mRNA expression of iNOS. Interestingly, (S)-dimers displayed a better bioactivity than (R)-dimers. These compounds may sever as lead candidates in the development of novel therapeutic drugs for RA treatment." @default.
- W2022378420 created "2016-06-24" @default.
- W2022378420 creator A5000032128 @default.
- W2022378420 creator A5006890585 @default.
- W2022378420 creator A5038832637 @default.
- W2022378420 creator A5055952405 @default.
- W2022378420 creator A5070253843 @default.
- W2022378420 creator A5071797918 @default.
- W2022378420 creator A5076707196 @default.
- W2022378420 creator A5081844561 @default.
- W2022378420 date "2011-05-01" @default.
- W2022378420 modified "2023-09-30" @default.
- W2022378420 title "Synthesis and biological evaluation of unique stereodimers of sinomenine analogues as potential inhibitors of NO production" @default.
- W2022378420 cites W1966434104 @default.
- W2022378420 cites W1967876873 @default.
- W2022378420 cites W1968470088 @default.
- W2022378420 cites W1970638605 @default.
- W2022378420 cites W1982093088 @default.
- W2022378420 cites W1994951045 @default.
- W2022378420 cites W2002633951 @default.
- W2022378420 cites W2005857572 @default.
- W2022378420 cites W2006112766 @default.
- W2022378420 cites W2009217186 @default.
- W2022378420 cites W2020921106 @default.
- W2022378420 cites W2026865649 @default.
- W2022378420 cites W2031708099 @default.
- W2022378420 cites W2043207258 @default.
- W2022378420 cites W2044532202 @default.
- W2022378420 cites W2051329655 @default.
- W2022378420 cites W2051796859 @default.
- W2022378420 cites W2053999933 @default.
- W2022378420 cites W2055580106 @default.
- W2022378420 cites W2056696036 @default.
- W2022378420 cites W2068019908 @default.
- W2022378420 cites W2071823872 @default.
- W2022378420 cites W2074187719 @default.
- W2022378420 cites W2080889392 @default.
- W2022378420 cites W2085597609 @default.
- W2022378420 cites W2091193879 @default.
- W2022378420 cites W2107386887 @default.
- W2022378420 cites W2117273044 @default.
- W2022378420 cites W2120677261 @default.
- W2022378420 cites W2148304657 @default.
- W2022378420 cites W2149026148 @default.
- W2022378420 cites W2152098493 @default.
- W2022378420 cites W2167545170 @default.
- W2022378420 cites W2181953632 @default.
- W2022378420 cites W2325496209 @default.
- W2022378420 cites W2949512038 @default.
- W2022378420 doi "https://doi.org/10.1016/j.bmc.2011.04.006" @default.
- W2022378420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21530276" @default.
- W2022378420 hasPublicationYear "2011" @default.
- W2022378420 type Work @default.
- W2022378420 sameAs 2022378420 @default.
- W2022378420 citedByCount "21" @default.
- W2022378420 countsByYear W20223784202012 @default.
- W2022378420 countsByYear W20223784202013 @default.
- W2022378420 countsByYear W20223784202015 @default.
- W2022378420 countsByYear W20223784202016 @default.
- W2022378420 countsByYear W20223784202017 @default.
- W2022378420 countsByYear W20223784202018 @default.
- W2022378420 countsByYear W20223784202019 @default.
- W2022378420 countsByYear W20223784202020 @default.
- W2022378420 countsByYear W20223784202021 @default.
- W2022378420 countsByYear W20223784202022 @default.
- W2022378420 countsByYear W20223784202023 @default.
- W2022378420 crossrefType "journal-article" @default.
- W2022378420 hasAuthorship W2022378420A5000032128 @default.
- W2022378420 hasAuthorship W2022378420A5006890585 @default.
- W2022378420 hasAuthorship W2022378420A5038832637 @default.
- W2022378420 hasAuthorship W2022378420A5055952405 @default.
- W2022378420 hasAuthorship W2022378420A5070253843 @default.
- W2022378420 hasAuthorship W2022378420A5071797918 @default.
- W2022378420 hasAuthorship W2022378420A5076707196 @default.
- W2022378420 hasAuthorship W2022378420A5081844561 @default.
- W2022378420 hasConcept C109316439 @default.
- W2022378420 hasConcept C169760540 @default.
- W2022378420 hasConcept C17077164 @default.
- W2022378420 hasConcept C185592680 @default.
- W2022378420 hasConcept C193042331 @default.
- W2022378420 hasConcept C202751555 @default.
- W2022378420 hasConcept C203014093 @default.
- W2022378420 hasConcept C2777575956 @default.
- W2022378420 hasConcept C2777662524 @default.
- W2022378420 hasConcept C2780783641 @default.
- W2022378420 hasConcept C55493867 @default.
- W2022378420 hasConcept C71924100 @default.
- W2022378420 hasConcept C86803240 @default.
- W2022378420 hasConcept C98274493 @default.
- W2022378420 hasConceptScore W2022378420C109316439 @default.
- W2022378420 hasConceptScore W2022378420C169760540 @default.
- W2022378420 hasConceptScore W2022378420C17077164 @default.
- W2022378420 hasConceptScore W2022378420C185592680 @default.
- W2022378420 hasConceptScore W2022378420C193042331 @default.
- W2022378420 hasConceptScore W2022378420C202751555 @default.
- W2022378420 hasConceptScore W2022378420C203014093 @default.
- W2022378420 hasConceptScore W2022378420C2777575956 @default.
- W2022378420 hasConceptScore W2022378420C2777662524 @default.