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• W2022378690 endingPage "S171" @default.
• W2022378690 startingPage "S161" @default.
• W2022378690 abstract "Gel electrophoresis can be used to separate nicked circular DNA molecules of equal length but forming different knot types. At low electric fields, complex knots drift faster than simpler knots. However, at high electric field the opposite is the case and simpler knots migrate faster than more complex knots. Using Monte Carlo simulations we investigate the reasons of this reversal of relative order of electrophoretic mobility of DNA molecules forming different knot types. We observe that at high electric fields the simulated knotted molecules tend to hang over the gel fibres and require passing over a substantial energy barrier to slip over the impeding gel fibre. At low electric field the interactions of drifting molecules with the gel fibres are weak and there are no significant energy barriers that oppose the detachment of knotted molecules from transverse gel fibres." @default.
• W2022378690 created "2016-06-24" @default.
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• W2022378690 date "2006-03-24" @default.
• W2022378690 modified "2023-10-02" @default.
• W2022378690 title "Simulations of electrophoretic collisions of DNA knots with gel obstacles" @default.
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• W2022378690 doi "https://doi.org/10.1088/0953-8984/18/14/s02" @default.
• W2022378690 hasPublicationYear "2006" @default.
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