FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022379382> ?p ?o ?g. }

• W2022379382 endingPage "64" @default.
• W2022379382 startingPage "58" @default.
• W2022379382 abstract "Polymeric nanoparticle dispersions containing dexamethasone (DXM) have been prepared from O/W nano-emulsions of the water/polysorbate 80/[4 wt% poly(lactide-co-glycolide) acid + 0.18 wt% DXM in ethyl acetate] system by a low-energy method at 25 °C. Nano-emulsions were formed at O/S ratios between 45/55 and 72/25 and water contents above 70 wt% by the phase inversion composition (PIC) method. The mean hydrodynamic diameter of nano-emulsions with a constant water content of 90 wt% and O/S ratios from 50/50 to 70/30 was below 350 nm as assessed by dynamic light scattering. The nanoparticles obtained from these nano-emulsions (by solvent evaporation) showed mean diameters of around 130 nm, as determined by transmission electron microscopy image analysis. Therapeutic concentrations of DXM were encapsulated in the nano-emulsions prior to nanoparticle preparation. DXM entrapment efficiency of the nanoparticle dispersion (above 74 wt%) decreased at increasing O/S ratios of the precursor nano-emulsion while DXM loading, which was around 10 mg/100 mL, showed the reverse tendency. DXM release from nanoparticle dispersions was about an order of magnitude slower than from an aqueous solution. In vitro studies performed in a lung carcinoma cell line and in vitro haemolysis studies performed in red blood cells revealed a dose-dependent toxicity and haemolytic response, respectively. The as-prepared nanoparticle dispersions were non-toxic up to a concentration of 40 μg/mL and non-haemolytic up to a concentration of 1 mg/mL. After purification, nanoparticle dispersions were non-toxic up to a concentration of 90 μg/mL. These results allow concluding that these polymeric nanoparticle dispersions are good candidates for inhalatory therapy." @default.
• W2022379382 created "2016-06-24" @default.
• W2022379382 creator A5002402281 @default.
• W2022379382 creator A5075020451 @default.
• W2022379382 creator A5076148230 @default.
• W2022379382 creator A5087928556 @default.
• W2022379382 date "2015-01-01" @default.
• W2022379382 modified "2023-09-26" @default.
• W2022379382 title "Design and in vitro evaluation of biocompatible dexamethasone-loaded nanoparticle dispersions, obtained from nano-emulsions, for inhalatory therapy" @default.
• W2022379382 cites W19380635 @default.
• W2022379382 cites W1967819079 @default.
• W2022379382 cites W1975823828 @default.
• W2022379382 cites W1976622025 @default.
• W2022379382 cites W1977149116 @default.
• W2022379382 cites W1980613333 @default.
• W2022379382 cites W1983756789 @default.
• W2022379382 cites W1984708466 @default.
• W2022379382 cites W1998245513 @default.
• W2022379382 cites W2001126914 @default.
• W2022379382 cites W2003275588 @default.
• W2022379382 cites W2005128563 @default.
• W2022379382 cites W2006920458 @default.
• W2022379382 cites W2007543270 @default.
• W2022379382 cites W2008730178 @default.
• W2022379382 cites W2009845520 @default.
• W2022379382 cites W2017323111 @default.
• W2022379382 cites W2048933340 @default.
• W2022379382 cites W2060351479 @default.
• W2022379382 cites W2061064248 @default.
• W2022379382 cites W2062020545 @default.
• W2022379382 cites W2066685510 @default.
• W2022379382 cites W2074467065 @default.
• W2022379382 cites W2083560987 @default.
• W2022379382 cites W2094690600 @default.
• W2022379382 cites W2100958444 @default.
• W2022379382 cites W2107766412 @default.
• W2022379382 cites W2135782311 @default.
• W2022379382 cites W2150471474 @default.
• W2022379382 cites W2163928377 @default.
• W2022379382 doi "https://doi.org/10.1016/j.colsurfb.2014.11.006" @default.
• W2022379382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25437064" @default.
• W2022379382 hasPublicationYear "2015" @default.
• W2022379382 type Work @default.
• W2022379382 sameAs 2022379382 @default.
• W2022379382 citedByCount "25" @default.
• W2022379382 countsByYear W20223793822015 @default.
• W2022379382 countsByYear W20223793822016 @default.
• W2022379382 countsByYear W20223793822017 @default.
• W2022379382 countsByYear W20223793822018 @default.
• W2022379382 countsByYear W20223793822019 @default.
• W2022379382 countsByYear W20223793822020 @default.
• W2022379382 countsByYear W20223793822021 @default.
• W2022379382 countsByYear W20223793822022 @default.
• W2022379382 countsByYear W20223793822023 @default.
• W2022379382 crossrefType "journal-article" @default.
• W2022379382 hasAuthorship W2022379382A5002402281 @default.
• W2022379382 hasAuthorship W2022379382A5075020451 @default.
• W2022379382 hasAuthorship W2022379382A5076148230 @default.
• W2022379382 hasAuthorship W2022379382A5087928556 @default.
• W2022379382 hasConcept C13965031 @default.
• W2022379382 hasConcept C14631669 @default.
• W2022379382 hasConcept C155672457 @default.
• W2022379382 hasConcept C171250308 @default.
• W2022379382 hasConcept C178790620 @default.
• W2022379382 hasConcept C185592680 @default.
• W2022379382 hasConcept C192562407 @default.
• W2022379382 hasConcept C203014093 @default.
• W2022379382 hasConcept C2778123984 @default.
• W2022379382 hasConcept C2910801743 @default.
• W2022379382 hasConcept C43617362 @default.
• W2022379382 hasConcept C59789625 @default.
• W2022379382 hasConcept C71924100 @default.
• W2022379382 hasConceptScore W2022379382C13965031 @default.
• W2022379382 hasConceptScore W2022379382C14631669 @default.
• W2022379382 hasConceptScore W2022379382C155672457 @default.
• W2022379382 hasConceptScore W2022379382C171250308 @default.
• W2022379382 hasConceptScore W2022379382C178790620 @default.
• W2022379382 hasConceptScore W2022379382C185592680 @default.
• W2022379382 hasConceptScore W2022379382C192562407 @default.
• W2022379382 hasConceptScore W2022379382C203014093 @default.
• W2022379382 hasConceptScore W2022379382C2778123984 @default.
• W2022379382 hasConceptScore W2022379382C2910801743 @default.
• W2022379382 hasConceptScore W2022379382C43617362 @default.
• W2022379382 hasConceptScore W2022379382C59789625 @default.
• W2022379382 hasConceptScore W2022379382C71924100 @default.
• W2022379382 hasFunder F4320321505 @default.
• W2022379382 hasFunder F4320321837 @default.
• W2022379382 hasFunder F4320334830 @default.
• W2022379382 hasLocation W20223793821 @default.
• W2022379382 hasLocation W20223793822 @default.
• W2022379382 hasOpenAccess W2022379382 @default.
• W2022379382 hasPrimaryLocation W20223793821 @default.
• W2022379382 hasRelatedWork W2029265473 @default.
• W2022379382 hasRelatedWork W2033458163 @default.
• W2022379382 hasRelatedWork W2128275152 @default.
• W2022379382 hasRelatedWork W2321131331 @default.
• W2022379382 hasRelatedWork W2326792112 @default.
• W2022379382 hasRelatedWork W2385611655 @default.

• next