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- W2022381518 abstract "An inclusion complex between naproxen and β-cyclodextrin was prepared by the freeze-drying method. Dissolution profiles in a pH 1.2 medium (gastric juice) of naproxen, freeze-dried naproxen, a physical mixture and 1:1 and 1:3 inclusion complexes demonstrated a faster dissolution rate of the inclusion complex. After 5 min the amount of drug dissolved was around 5% for the drug, 12% for freeze-dried naproxen, 11% for the physical mixture and 61 and 99% for the 1:1 and 1:3 inclusion complexes, respectively. The bioavailability of naproxen administered as its 1:1 inclusion complex with β-cyclodextrin has been evaluated using a new HPLC method for determining the drug and its glucuronide conjugate in urine. Renal excretion levels after oral administrations of naproxen, freeze-dried naproxen and the 1:1 inclusion complex with β-cyclodextrin, measured by this method, show no statistical differences, indicating that the three formulations assayed are bioequivalent." @default.
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- W2022381518 date "1991-08-01" @default.
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- W2022381518 title "Oral bioavailability of naproxen-β-cyclodextrin inclusion compound" @default.
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- W2022381518 doi "https://doi.org/10.1016/0378-5173(91)90248-m" @default.
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