Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022381632> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2022381632 endingPage "786" @default.
- W2022381632 startingPage "771" @default.
- W2022381632 abstract "Narcolepsy is a chronic hypersomnia characterized by excessive daytime sleepiness (EDS) and manifestations of disrupted rapid eye movement sleep stage (cataplexy, sleep paralysis, and hypnagogic/hypnopompic hallucinations). Mechanisms underlying narcolepsy are not fully understood. Experimental data indicate that the disease is caused by a loss of hypocretin neurons in the hypothalamus, likely due to an autoimmune process triggered by environmental factors in susceptible individuals. Most patients with narcolepsy and cataplexy have very low hypocretin-1 levels in the cerebrospinal fluid. An appropriate clinical history, polysomnogram, and multiple sleep latency test are necessary for diagnosis of the disease. Additionally, two biological markers, i.e., cerebrospinal fluid hypocretin-1 levels and expression of the DQB1*0602 gene, are used. The treatment of narcolepsy is aimed at the different symptoms that the patient manifests. Excessive daytime sleepiness is treated with psychostimulants (amphetamine-like, modafinil and armodafinil). Cataplexy is treated with sodium oxybate (GHB), tricyclic antidepressants, or selective serotonin and noradrenaline reuptake inhibitors. Sleep paralysis, hallucinations, and fragmented sleep may be treated with sodium oxybate. Patients with narcolepsy should follow proper sleep hygiene and avoid strong emotions." @default.
- W2022381632 created "2016-06-24" @default.
- W2022381632 creator A5038460349 @default.
- W2022381632 creator A5054985094 @default.
- W2022381632 creator A5069959118 @default.
- W2022381632 creator A5078509687 @default.
- W2022381632 creator A5080547374 @default.
- W2022381632 date "2012-10-24" @default.
- W2022381632 modified "2023-09-26" @default.
- W2022381632 title "Narcolepsy: etiology, clinical features, diagnosis and treatment" @default.
- W2022381632 doi "https://doi.org/10.5604/17322693.1015529" @default.
- W2022381632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23175331" @default.
- W2022381632 hasPublicationYear "2012" @default.
- W2022381632 type Work @default.
- W2022381632 sameAs 2022381632 @default.
- W2022381632 citedByCount "4" @default.
- W2022381632 countsByYear W20223816322014 @default.
- W2022381632 countsByYear W20223816322015 @default.
- W2022381632 crossrefType "journal-article" @default.
- W2022381632 hasAuthorship W2022381632A5038460349 @default.
- W2022381632 hasAuthorship W2022381632A5054985094 @default.
- W2022381632 hasAuthorship W2022381632A5069959118 @default.
- W2022381632 hasAuthorship W2022381632A5078509687 @default.
- W2022381632 hasAuthorship W2022381632A5080547374 @default.
- W2022381632 hasBestOaLocation W20223816321 @default.
- W2022381632 hasConcept C118303440 @default.
- W2022381632 hasConcept C118552586 @default.
- W2022381632 hasConcept C126322002 @default.
- W2022381632 hasConcept C1513209611 @default.
- W2022381632 hasConcept C15744967 @default.
- W2022381632 hasConcept C170493617 @default.
- W2022381632 hasConcept C2777133385 @default.
- W2022381632 hasConcept C2777446050 @default.
- W2022381632 hasConcept C2779494582 @default.
- W2022381632 hasConcept C2779680196 @default.
- W2022381632 hasConcept C2780163352 @default.
- W2022381632 hasConcept C2780714222 @default.
- W2022381632 hasConcept C2781210498 @default.
- W2022381632 hasConcept C2781433485 @default.
- W2022381632 hasConcept C42219234 @default.
- W2022381632 hasConcept C71924100 @default.
- W2022381632 hasConceptScore W2022381632C118303440 @default.
- W2022381632 hasConceptScore W2022381632C118552586 @default.
- W2022381632 hasConceptScore W2022381632C126322002 @default.
- W2022381632 hasConceptScore W2022381632C1513209611 @default.
- W2022381632 hasConceptScore W2022381632C15744967 @default.
- W2022381632 hasConceptScore W2022381632C170493617 @default.
- W2022381632 hasConceptScore W2022381632C2777133385 @default.
- W2022381632 hasConceptScore W2022381632C2777446050 @default.
- W2022381632 hasConceptScore W2022381632C2779494582 @default.
- W2022381632 hasConceptScore W2022381632C2779680196 @default.
- W2022381632 hasConceptScore W2022381632C2780163352 @default.
- W2022381632 hasConceptScore W2022381632C2780714222 @default.
- W2022381632 hasConceptScore W2022381632C2781210498 @default.
- W2022381632 hasConceptScore W2022381632C2781433485 @default.
- W2022381632 hasConceptScore W2022381632C42219234 @default.
- W2022381632 hasConceptScore W2022381632C71924100 @default.
- W2022381632 hasLocation W20223816321 @default.
- W2022381632 hasLocation W20223816322 @default.
- W2022381632 hasLocation W20223816323 @default.
- W2022381632 hasOpenAccess W2022381632 @default.
- W2022381632 hasPrimaryLocation W20223816321 @default.
- W2022381632 hasRelatedWork W1564127985 @default.
- W2022381632 hasRelatedWork W1985076823 @default.
- W2022381632 hasRelatedWork W2022381632 @default.
- W2022381632 hasRelatedWork W2033531639 @default.
- W2022381632 hasRelatedWork W2060552085 @default.
- W2022381632 hasRelatedWork W2097842946 @default.
- W2022381632 hasRelatedWork W2112607008 @default.
- W2022381632 hasRelatedWork W2397676504 @default.
- W2022381632 hasRelatedWork W2517280725 @default.
- W2022381632 hasRelatedWork W3023507185 @default.
- W2022381632 hasVolume "66" @default.
- W2022381632 isParatext "false" @default.
- W2022381632 isRetracted "false" @default.
- W2022381632 magId "2022381632" @default.
- W2022381632 workType "article" @default.