Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022381731> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2022381731 endingPage "734" @default.
- W2022381731 startingPage "727" @default.
- W2022381731 abstract "The ovulatory agent clomiphene citrate, a racemic mixture of the estrogenic zuclomiphene and antiestrogenic enclomiphene isomers, has been associated with gamete/embryo toxicity in various animal models. To assess the potential effects of these isomers on fertilization and early embryogenesis, 3200 embryos were obtained from mouse oocytes fertilized in vivo and in vitro and exposed to increasing concentrations of zuclomiphene, enclomiphene, and clomiphene citrate in culture. Fertilization rates (p less than 0.01), blastocyst formation rates (p less than 0.02), and degeneration rates (p less than 0.005) were all adversely affected in a dose-dependent fashion. There were no statistically significant differences between the two isomers. Preincubation with 17 beta-estradiol did decrease the degenerative changes induced by clomiphene citrate but did not improve the decreased rate of blastocyst formation. These findings suggest adverse effects of a high concentration of clomiphene citrate and its isomers on fertilization and early mouse embryo growth that may have implications in the clinical use of this drug." @default.
- W2022381731 created "2016-06-24" @default.
- W2022381731 creator A5003993599 @default.
- W2022381731 creator A5011470161 @default.
- W2022381731 creator A5058024848 @default.
- W2022381731 creator A5081604936 @default.
- W2022381731 creator A5090379700 @default.
- W2022381731 date "1986-04-01" @default.
- W2022381731 modified "2023-09-27" @default.
- W2022381731 title "The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo" @default.
- W2022381731 cites W138858130 @default.
- W2022381731 cites W1595170675 @default.
- W2022381731 cites W1963595907 @default.
- W2022381731 cites W2015961272 @default.
- W2022381731 cites W2023958944 @default.
- W2022381731 cites W2029406824 @default.
- W2022381731 cites W2042222847 @default.
- W2022381731 cites W2169176998 @default.
- W2022381731 cites W2275035913 @default.
- W2022381731 cites W2276701099 @default.
- W2022381731 cites W2412875632 @default.
- W2022381731 cites W2413850626 @default.
- W2022381731 cites W2428294708 @default.
- W2022381731 doi "https://doi.org/10.1016/0002-9378(86)90444-8" @default.
- W2022381731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3083679" @default.
- W2022381731 hasPublicationYear "1986" @default.
- W2022381731 type Work @default.
- W2022381731 sameAs 2022381731 @default.
- W2022381731 citedByCount "36" @default.
- W2022381731 countsByYear W20223817312014 @default.
- W2022381731 countsByYear W20223817312016 @default.
- W2022381731 countsByYear W20223817312023 @default.
- W2022381731 crossrefType "journal-article" @default.
- W2022381731 hasAuthorship W2022381731A5003993599 @default.
- W2022381731 hasAuthorship W2022381731A5011470161 @default.
- W2022381731 hasAuthorship W2022381731A5058024848 @default.
- W2022381731 hasAuthorship W2022381731A5081604936 @default.
- W2022381731 hasAuthorship W2022381731A5090379700 @default.
- W2022381731 hasConcept C105702510 @default.
- W2022381731 hasConcept C126322002 @default.
- W2022381731 hasConcept C134018914 @default.
- W2022381731 hasConcept C16685009 @default.
- W2022381731 hasConcept C196843134 @default.
- W2022381731 hasConcept C202751555 @default.
- W2022381731 hasConcept C207001950 @default.
- W2022381731 hasConcept C2776803348 @default.
- W2022381731 hasConcept C2778177303 @default.
- W2022381731 hasConcept C29730261 @default.
- W2022381731 hasConcept C512716672 @default.
- W2022381731 hasConcept C54355233 @default.
- W2022381731 hasConcept C55493867 @default.
- W2022381731 hasConcept C71924100 @default.
- W2022381731 hasConcept C86803240 @default.
- W2022381731 hasConcept C87073359 @default.
- W2022381731 hasConcept C88972607 @default.
- W2022381731 hasConceptScore W2022381731C105702510 @default.
- W2022381731 hasConceptScore W2022381731C126322002 @default.
- W2022381731 hasConceptScore W2022381731C134018914 @default.
- W2022381731 hasConceptScore W2022381731C16685009 @default.
- W2022381731 hasConceptScore W2022381731C196843134 @default.
- W2022381731 hasConceptScore W2022381731C202751555 @default.
- W2022381731 hasConceptScore W2022381731C207001950 @default.
- W2022381731 hasConceptScore W2022381731C2776803348 @default.
- W2022381731 hasConceptScore W2022381731C2778177303 @default.
- W2022381731 hasConceptScore W2022381731C29730261 @default.
- W2022381731 hasConceptScore W2022381731C512716672 @default.
- W2022381731 hasConceptScore W2022381731C54355233 @default.
- W2022381731 hasConceptScore W2022381731C55493867 @default.
- W2022381731 hasConceptScore W2022381731C71924100 @default.
- W2022381731 hasConceptScore W2022381731C86803240 @default.
- W2022381731 hasConceptScore W2022381731C87073359 @default.
- W2022381731 hasConceptScore W2022381731C88972607 @default.
- W2022381731 hasIssue "4" @default.
- W2022381731 hasLocation W20223817311 @default.
- W2022381731 hasLocation W20223817312 @default.
- W2022381731 hasOpenAccess W2022381731 @default.
- W2022381731 hasPrimaryLocation W20223817311 @default.
- W2022381731 hasRelatedWork W1983333251 @default.
- W2022381731 hasRelatedWork W2046745697 @default.
- W2022381731 hasRelatedWork W2114891781 @default.
- W2022381731 hasRelatedWork W2138420421 @default.
- W2022381731 hasRelatedWork W2158413590 @default.
- W2022381731 hasRelatedWork W2166971475 @default.
- W2022381731 hasRelatedWork W2349296746 @default.
- W2022381731 hasRelatedWork W2389182588 @default.
- W2022381731 hasRelatedWork W3139799459 @default.
- W2022381731 hasRelatedWork W5535762 @default.
- W2022381731 hasVolume "154" @default.
- W2022381731 isParatext "false" @default.
- W2022381731 isRetracted "false" @default.
- W2022381731 magId "2022381731" @default.
- W2022381731 workType "article" @default.