FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022382089> ?p ?o ?g. }

• W2022382089 endingPage "e73800" @default.
• W2022382089 startingPage "e73800" @default.
• W2022382089 abstract "Twenty-five years of Australian marine bioresources collecting and research by the Australian Institute of Marine Science (AIMS) has explored the breadth of latitudinally and longitudinally diverse marine habitats that comprise Australia’s ocean territory. The resulting AIMS Bioresources Library and associated relational database integrate biodiversity with bioactivity data, and these resources were mined to retrospectively assess biogeographic, taxonomic and phylogenetic patterns in cytotoxic, antimicrobial, and central nervous system (CNS)-protective bioactivity. While the bioassays used were originally chosen to be indicative of pharmaceutically relevant bioactivity, the results have qualified ecological relevance regarding secondary metabolism. In general, metazoan phyla along the deuterostome phylogenetic pathway (eg to Chordata) and their ancestors (eg Porifera and Cnidaria) had higher percentages of bioactive samples in the assays examined. While taxonomy at the phylum level and higher-order phylogeny groupings helped account for observed trends, taxonomy to genus did not resolve the trends any further. In addition, the results did not identify any biogeographic bioactivity hotspots that correlated with biodiversity hotspots. We conclude with a hypothesis that high-level phylogeny, and therefore the metabolic machinery available to an organism, is a major determinant of bioactivity, while habitat diversity and ecological circumstance are possible drivers in the activation of this machinery and bioactive secondary metabolism. This study supports the strategy of targeting phyla from the deuterostome lineage (including ancestral phyla) from biodiverse marine habitats and ecological niches, in future biodiscovery, at least that which is focused on vertebrate (including human) health." @default.
• W2022382089 created "2016-06-24" @default.
• W2022382089 creator A5000413163 @default.
• W2022382089 creator A5002587980 @default.
• W2022382089 creator A5008413831 @default.
• W2022382089 creator A5017033733 @default.
• W2022382089 creator A5018728273 @default.
• W2022382089 creator A5023912283 @default.
• W2022382089 creator A5030864773 @default.
• W2022382089 creator A5052443945 @default.
• W2022382089 creator A5061885016 @default.
• W2022382089 creator A5070655025 @default.
• W2022382089 creator A5080740226 @default.
• W2022382089 creator A5090192832 @default.
• W2022382089 date "2013-09-05" @default.
• W2022382089 modified "2023-10-15" @default.
• W2022382089 title "Phylogeny Drives Large Scale Patterns in Australian Marine Bioactivity and Provides a New Chemical Ecology Rationale for Future Biodiscovery" @default.
• W2022382089 cites W103412809 @default.
• W2022382089 cites W1487271490 @default.
• W2022382089 cites W1504523189 @default.
• W2022382089 cites W1516692825 @default.
• W2022382089 cites W1541598331 @default.
• W2022382089 cites W1578612956 @default.
• W2022382089 cites W1597831621 @default.
• W2022382089 cites W1828207679 @default.
• W2022382089 cites W1964352126 @default.
• W2022382089 cites W1966048672 @default.
• W2022382089 cites W1968292938 @default.
• W2022382089 cites W1981287076 @default.
• W2022382089 cites W1981457167 @default.
• W2022382089 cites W1986258214 @default.
• W2022382089 cites W1989777548 @default.
• W2022382089 cites W1992246428 @default.
• W2022382089 cites W1994056761 @default.
• W2022382089 cites W2004556975 @default.
• W2022382089 cites W2007100618 @default.
• W2022382089 cites W2008100916 @default.
• W2022382089 cites W2009020477 @default.
• W2022382089 cites W2011618995 @default.
• W2022382089 cites W2017581522 @default.
• W2022382089 cites W2018568304 @default.
• W2022382089 cites W2026813249 @default.
• W2022382089 cites W2026844309 @default.
• W2022382089 cites W2027347467 @default.
• W2022382089 cites W2034614648 @default.
• W2022382089 cites W2046048669 @default.
• W2022382089 cites W2048559125 @default.
• W2022382089 cites W2051585679 @default.
• W2022382089 cites W2057434525 @default.
• W2022382089 cites W2069289573 @default.
• W2022382089 cites W2076159465 @default.
• W2022382089 cites W2077728293 @default.
• W2022382089 cites W2080936544 @default.
• W2022382089 cites W2081479020 @default.
• W2022382089 cites W2081836531 @default.
• W2022382089 cites W2082049684 @default.
• W2022382089 cites W2084829738 @default.
• W2022382089 cites W2086871241 @default.
• W2022382089 cites W2089625544 @default.
• W2022382089 cites W2090522274 @default.
• W2022382089 cites W2097315307 @default.
• W2022382089 cites W2099535402 @default.
• W2022382089 cites W2102828101 @default.
• W2022382089 cites W2114395497 @default.
• W2022382089 cites W2115675984 @default.
• W2022382089 cites W2116480064 @default.
• W2022382089 cites W2117954460 @default.
• W2022382089 cites W2118886763 @default.
• W2022382089 cites W2120687358 @default.
• W2022382089 cites W2128942357 @default.
• W2022382089 cites W2132120234 @default.
• W2022382089 cites W2139328513 @default.
• W2022382089 cites W2141474275 @default.
• W2022382089 cites W2147378897 @default.
• W2022382089 cites W2149427712 @default.
• W2022382089 cites W2149529243 @default.
• W2022382089 cites W2158561725 @default.
• W2022382089 cites W2167298815 @default.
• W2022382089 cites W2171682691 @default.
• W2022382089 cites W251764212 @default.
• W2022382089 cites W2949527296 @default.
• W2022382089 cites W4211006984 @default.
• W2022382089 cites W4238538390 @default.
• W2022382089 cites W4240487363 @default.
• W2022382089 cites W4243883191 @default.
• W2022382089 cites W92572262 @default.
• W2022382089 doi "https://doi.org/10.1371/journal.pone.0073800" @default.
• W2022382089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3763996" @default.
• W2022382089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24040076" @default.
• W2022382089 hasPublicationYear "2013" @default.
• W2022382089 type Work @default.
• W2022382089 sameAs 2022382089 @default.
• W2022382089 citedByCount "24" @default.
• W2022382089 countsByYear W20223820892014 @default.
• W2022382089 countsByYear W20223820892015 @default.
• W2022382089 countsByYear W20223820892016 @default.
• W2022382089 countsByYear W20223820892017 @default.
• W2022382089 countsByYear W20223820892018 @default.

• next