FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022382264> ?p ?o ?g. }

• W2022382264 endingPage "136" @default.
• W2022382264 startingPage "129" @default.
• W2022382264 abstract "Experiments were done to determine the actions of ACTH on the morphologic and functional characteristics of the zona fasciculata (ZF) and zona reticularis (ZR) in the guinea pig adrenal cortex. In control guinea pigs, a number of morphologic differences distinguished the ZF from the ZR, including the presence of far more lipid in the ZF than in the ZR. Treatment with ACTH decreased the lipid droplet content of the ZF cells, equalizing the amount of lipid in the two zones. Other morphologic differences between the ZF and ZR were also diminished by ACTH treatment. Immunohistochemical analyses indicated that CYP17 protein was found in both the ZF and ZR in control animals, but with greater immunostaining intensity in the ZF. The enzyme protein distribution corresponded with higher 17α-hydroxylase activity in the ZF than in the ZR. After ACTH treatment, the intensity of staining and enzyme activities in the two zones were similar, attributable largely to increases in the ZR. In situ hybridization and immunohistochemistry showed that in control animals CYPD216 was highly expressed in the ZR but not in the ZF. ACTH treatment dramatically reduced the intensity of CYP2D16 mRNA and protein staining in the ZR. Bufuralol 1′-hydroxylase activity, a marker for CYP2D subfamily members, was also decreased significantly in the ZR by ACTH treatment. The data indicate that administration of ACTH to guinea pigs has opposite effects on the expression of CYP17 and CYP2D16 in the ZR, and diminishes or eliminates some of the structural and functional differences between the ZF and ZR. The results suggest a role for ACTH in establishing and maintaining adrenocortical zonation." @default.
• W2022382264 created "2016-06-24" @default.
• W2022382264 creator A5002263742 @default.
• W2022382264 creator A5011642310 @default.
• W2022382264 creator A5031891304 @default.
• W2022382264 creator A5036137017 @default.
• W2022382264 creator A5072068799 @default.
• W2022382264 date "1998-11-01" @default.
• W2022382264 modified "2023-09-26" @default.
• W2022382264 title "Effects of ACTH administration on zonation of the guinea pig adrenal cortex" @default.
• W2022382264 cites W1969215912 @default.
• W2022382264 cites W1981432626 @default.
• W2022382264 cites W2009096269 @default.
• W2022382264 cites W2009875926 @default.
• W2022382264 cites W2016684961 @default.
• W2022382264 cites W2017431020 @default.
• W2022382264 cites W2018429582 @default.
• W2022382264 cites W2021248021 @default.
• W2022382264 cites W2021290181 @default.
• W2022382264 cites W2035783341 @default.
• W2022382264 cites W2036509589 @default.
• W2022382264 cites W2036724567 @default.
• W2022382264 cites W2049181029 @default.
• W2022382264 cites W2052535074 @default.
• W2022382264 cites W2071057912 @default.
• W2022382264 cites W2075324604 @default.
• W2022382264 cites W2083636680 @default.
• W2022382264 cites W2093202242 @default.
• W2022382264 cites W2151802894 @default.
• W2022382264 doi "https://doi.org/10.1016/s0303-7207(98)00189-0" @default.
• W2022382264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10022770" @default.
• W2022382264 hasPublicationYear "1998" @default.
• W2022382264 type Work @default.
• W2022382264 sameAs 2022382264 @default.
• W2022382264 citedByCount "8" @default.
• W2022382264 countsByYear W20223822642016 @default.
• W2022382264 countsByYear W20223822642017 @default.
• W2022382264 crossrefType "journal-article" @default.
• W2022382264 hasAuthorship W2022382264A5002263742 @default.
• W2022382264 hasAuthorship W2022382264A5011642310 @default.
• W2022382264 hasAuthorship W2022382264A5031891304 @default.
• W2022382264 hasAuthorship W2022382264A5036137017 @default.
• W2022382264 hasAuthorship W2022382264A5072068799 @default.
• W2022382264 hasConcept C104317684 @default.
• W2022382264 hasConcept C105580179 @default.
• W2022382264 hasConcept C126322002 @default.
• W2022382264 hasConcept C134018914 @default.
• W2022382264 hasConcept C185592680 @default.
• W2022382264 hasConcept C204232928 @default.
• W2022382264 hasConcept C25095133 @default.
• W2022382264 hasConcept C2777784954 @default.
• W2022382264 hasConcept C2777977426 @default.
• W2022382264 hasConcept C2778736161 @default.
• W2022382264 hasConcept C2778815084 @default.
• W2022382264 hasConcept C2780178468 @default.
• W2022382264 hasConcept C2908929049 @default.
• W2022382264 hasConcept C4224716 @default.
• W2022382264 hasConcept C54355233 @default.
• W2022382264 hasConcept C55493867 @default.
• W2022382264 hasConcept C71924100 @default.
• W2022382264 hasConcept C74864618 @default.
• W2022382264 hasConcept C81439078 @default.
• W2022382264 hasConcept C84393581 @default.
• W2022382264 hasConcept C86803240 @default.
• W2022382264 hasConceptScore W2022382264C104317684 @default.
• W2022382264 hasConceptScore W2022382264C105580179 @default.
• W2022382264 hasConceptScore W2022382264C126322002 @default.
• W2022382264 hasConceptScore W2022382264C134018914 @default.
• W2022382264 hasConceptScore W2022382264C185592680 @default.
• W2022382264 hasConceptScore W2022382264C204232928 @default.
• W2022382264 hasConceptScore W2022382264C25095133 @default.
• W2022382264 hasConceptScore W2022382264C2777784954 @default.
• W2022382264 hasConceptScore W2022382264C2777977426 @default.
• W2022382264 hasConceptScore W2022382264C2778736161 @default.
• W2022382264 hasConceptScore W2022382264C2778815084 @default.
• W2022382264 hasConceptScore W2022382264C2780178468 @default.
• W2022382264 hasConceptScore W2022382264C2908929049 @default.
• W2022382264 hasConceptScore W2022382264C4224716 @default.
• W2022382264 hasConceptScore W2022382264C54355233 @default.
• W2022382264 hasConceptScore W2022382264C55493867 @default.
• W2022382264 hasConceptScore W2022382264C71924100 @default.
• W2022382264 hasConceptScore W2022382264C74864618 @default.
• W2022382264 hasConceptScore W2022382264C81439078 @default.
• W2022382264 hasConceptScore W2022382264C84393581 @default.
• W2022382264 hasConceptScore W2022382264C86803240 @default.
• W2022382264 hasFunder F4320332505 @default.
• W2022382264 hasFunder F4320337337 @default.
• W2022382264 hasIssue "1-2" @default.
• W2022382264 hasLocation W20223822641 @default.
• W2022382264 hasLocation W20223822642 @default.
• W2022382264 hasOpenAccess W2022382264 @default.
• W2022382264 hasPrimaryLocation W20223822641 @default.
• W2022382264 hasRelatedWork W172004455 @default.
• W2022382264 hasRelatedWork W1967356557 @default.
• W2022382264 hasRelatedWork W2009952201 @default.
• W2022382264 hasRelatedWork W2010033647 @default.
• W2022382264 hasRelatedWork W2068263482 @default.
• W2022382264 hasRelatedWork W2083636680 @default.

• next