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- W2022382393 abstract "Abstract 1. 1. An analysis of the NADH(NADPH):(acceptor) oxidoreductase activities of adrenal chromaffin granules depleted of low molecular weight substances (notably catecholamines and ATP), has been made in terms of the flavoprotein(s) and cytochrome b 561 previously reported (Flatmark, T., Terland, O. and Helle, K. B. (1971) Biochim. Biophys. Acta 226, 9–19). 2. 2. The overall NADH oxidation of freshly prepared granule preparations was rather low (0.06–0.32 nmole NADH oxidized per min per mg of protein; n = 21), but approximately 10 times higher than the NADPH oxidation (0-0.04 nmole NADPH oxidized per min per mg of protein; n = 6). 3. 3. Of the total NADH oxidase activity of the granule preparation approximately 45% was attributed to an oxidative sequence involving a p -hydroxymercuribenzoate (PHMB)-sensitive flavoprotein, cytochrome b 561 and a cyanide-sensitive oxidase. This NADH oxidase activity was greatly stimulated by mammalian cytochrome c ( K ′ m = 1.6 · 10 −6 M) and resembled the microsomal activity, e.g. of liver, in its insensitivity to antimycin A. Approximately 45% of the NADH oxidase activity was attributed to an oxidative sequence probably involving a flavoprotein and an endogenous electron acceptor. This activity was inhibited only at high concentrations of PHMB and was stimulated by fumarate. An additional 10% of the NADH oxidation was completely insensitive to PHMB as well as to cyanide and revealed the same specific activity with NADPH. 4. 4. The NADH(NADPH): (acceptor) oxidoreductase activities vary according to the structural state of the membrane phase. Thus, the oxidative reactions suffer profound changes upon disintegration of the membrane structure by various means, e.g. by dilution (particularly at higher temperatures) and by detergent (Triton X-100). One of the most remarkable features of this transition was the appearance of a fumarate-stimulated oxidation of NADH which did not require molecular oxygen, but could be accounted for on the basis of the presence of an endogenous electron acceptor of molecular weight" @default.
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- W2022382393 date "1973-05-01" @default.
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- W2022382393 title "NADH(NADPH):(Acceptor) oxidoreductase activities of the bovine adrenal chromaffin granules" @default.
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- W2022382393 doi "https://doi.org/10.1016/0005-2728(73)90170-9" @default.
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