FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022382803> ?p ?o ?g. }

• W2022382803 endingPage "4911" @default.
• W2022382803 startingPage "4906" @default.
• W2022382803 abstract "The cellular cytoskeleton is a complex dynamical network that constantly remodels as cells divide and move. This reorganization process occurs not only at the cell membrane, but also in the cell interior (bulk). During locomotion, regulated actin assembly near the plasma membrane produces lamellipodia and filopodia. Therefore, most in vitro experiments explore phenomena taking place in the vicinity of a surface. To understand how the molecular machinery of a cell self-organizes in a more general way, we studied bulk polymerization of actin in the presence of actin-related protein 2/3 complex and a nucleation promoting factor as a model for actin assembly in the cell interior separate from membranes. Bulk polymerization of actin in the presence of the verprolin homology, cofilin homology, and acidic region, domain of Wiskott-Aldrich syndrome protein, and actin-related protein 2/3 complex results in spontaneous formation of diffuse aster-like structures. In the presence of fascin these asters transition into stars with bundles of actin filaments growing from the surface, similar to star-like structures recently observed in vivo . The transition from asters to stars depends on the ratio [fascin]/[G actin]. The polarity of the actin filaments during the transition is preserved, as in the transition from lamellipodia to filopodia. Capping protein inhibits star formation. Based on these experiments and kinetic Monte Carlo simulations, we propose a model for the spontaneous self-assembly of asters and their transition into stars. This mechanism may apply to the transition from lamellipodia to filopodia in vivo ." @default.
• W2022382803 created "2016-06-24" @default.
• W2022382803 creator A5001305035 @default.
• W2022382803 creator A5002824354 @default.
• W2022382803 creator A5028583059 @default.
• W2022382803 creator A5043478405 @default.
• W2022382803 creator A5067215274 @default.
• W2022382803 creator A5070605010 @default.
• W2022382803 creator A5089849625 @default.
• W2022382803 date "2006-03-20" @default.
• W2022382803 modified "2023-09-23" @default.
• W2022382803 title "Reconstitution of the transition from lamellipodium to filopodium in a membrane-free system" @default.
• W2022382803 cites W1538692246 @default.
• W2022382803 cites W1593929303 @default.
• W2022382803 cites W1635520329 @default.
• W2022382803 cites W1960862471 @default.
• W2022382803 cites W1985411135 @default.
• W2022382803 cites W2001043279 @default.
• W2022382803 cites W2014906153 @default.
• W2022382803 cites W2018730824 @default.
• W2022382803 cites W2025957398 @default.
• W2022382803 cites W2029189987 @default.
• W2022382803 cites W2049811440 @default.
• W2022382803 cites W2053431375 @default.
• W2022382803 cites W2055466007 @default.
• W2022382803 cites W2056902230 @default.
• W2022382803 cites W2057633698 @default.
• W2022382803 cites W2062941196 @default.
• W2022382803 cites W2071156082 @default.
• W2022382803 cites W2082677295 @default.
• W2022382803 cites W2090355988 @default.
• W2022382803 cites W2098173227 @default.
• W2022382803 cites W2102701307 @default.
• W2022382803 cites W2105789974 @default.
• W2022382803 cites W2108167818 @default.
• W2022382803 cites W2108262896 @default.
• W2022382803 cites W2118875203 @default.
• W2022382803 cites W2121588102 @default.
• W2022382803 cites W2124189388 @default.
• W2022382803 cites W2126496496 @default.
• W2022382803 cites W2126893470 @default.
• W2022382803 cites W2145658691 @default.
• W2022382803 cites W2146894615 @default.
• W2022382803 cites W2155653297 @default.
• W2022382803 cites W2161042020 @default.
• W2022382803 cites W2161916354 @default.
• W2022382803 doi "https://doi.org/10.1073/pnas.0508269103" @default.
• W2022382803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1458768" @default.
• W2022382803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16549794" @default.
• W2022382803 hasPublicationYear "2006" @default.
• W2022382803 type Work @default.
• W2022382803 sameAs 2022382803 @default.
• W2022382803 citedByCount "79" @default.
• W2022382803 countsByYear W20223828032012 @default.
• W2022382803 countsByYear W20223828032013 @default.
• W2022382803 countsByYear W20223828032014 @default.
• W2022382803 countsByYear W20223828032015 @default.
• W2022382803 countsByYear W20223828032016 @default.
• W2022382803 countsByYear W20223828032017 @default.
• W2022382803 countsByYear W20223828032018 @default.
• W2022382803 countsByYear W20223828032019 @default.
• W2022382803 countsByYear W20223828032020 @default.
• W2022382803 countsByYear W20223828032021 @default.
• W2022382803 countsByYear W20223828032022 @default.
• W2022382803 countsByYear W20223828032023 @default.
• W2022382803 crossrefType "journal-article" @default.
• W2022382803 hasAuthorship W2022382803A5001305035 @default.
• W2022382803 hasAuthorship W2022382803A5002824354 @default.
• W2022382803 hasAuthorship W2022382803A5028583059 @default.
• W2022382803 hasAuthorship W2022382803A5043478405 @default.
• W2022382803 hasAuthorship W2022382803A5067215274 @default.
• W2022382803 hasAuthorship W2022382803A5070605010 @default.
• W2022382803 hasAuthorship W2022382803A5089849625 @default.
• W2022382803 hasBestOaLocation W20223828032 @default.
• W2022382803 hasConcept C109185818 @default.
• W2022382803 hasConcept C12554922 @default.
• W2022382803 hasConcept C125705527 @default.
• W2022382803 hasConcept C142669718 @default.
• W2022382803 hasConcept C1491633281 @default.
• W2022382803 hasConcept C151000934 @default.
• W2022382803 hasConcept C189040839 @default.
• W2022382803 hasConcept C199528912 @default.
• W2022382803 hasConcept C203253989 @default.
• W2022382803 hasConcept C2778934503 @default.
• W2022382803 hasConcept C2993400109 @default.
• W2022382803 hasConcept C3620293 @default.
• W2022382803 hasConcept C55493867 @default.
• W2022382803 hasConcept C59999672 @default.
• W2022382803 hasConcept C86803240 @default.
• W2022382803 hasConcept C90301020 @default.
• W2022382803 hasConcept C95444343 @default.
• W2022382803 hasConceptScore W2022382803C109185818 @default.
• W2022382803 hasConceptScore W2022382803C12554922 @default.
• W2022382803 hasConceptScore W2022382803C125705527 @default.
• W2022382803 hasConceptScore W2022382803C142669718 @default.
• W2022382803 hasConceptScore W2022382803C1491633281 @default.
• W2022382803 hasConceptScore W2022382803C151000934 @default.
• W2022382803 hasConceptScore W2022382803C189040839 @default.

• next