Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022383654> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2022383654 endingPage "87" @default.
- W2022383654 startingPage "85" @default.
- W2022383654 abstract "The efficacy of 5-iodo-2-deoxyuridine (IUDR) as a radiosensitizer when administered by continuous infusion into the cerebral spinal fluid (CSF) of the lateral cerebral ventricle was evaluated in a 9L gliosarcoma rat brain tumor model. Stereotactic implantation of a 5 x 10(4) tumor cell suspension into the left caudate nucleus was carried out in four groups of 10 rats each. Control animals had a median survival of 16.9 days (range 16-21 days). IUDR, 8.4 mg over 7 days administered by continuous infusion into the left lateral ventricle produced a slight survival advantage (median survival 21.5 days, range 12-56). Irradiation of the entire brain, 8 Gy on days 4, 6 and 7 after tumor cell implantation also produced a slight improvement in survival (median 19.5 days, range 17-34). The combination of radiation and IUDR infusion into the CSF produced a marked survival advantage (median 30.5, range 22-54) compared to the control and single modality treatment groups. This is the first demonstration of the effectiveness of IUDR as a radiosensitizer when administered into the lateral cerebral ventricle in the treatment of an intraparenchymal brain tumor." @default.
- W2022383654 created "2016-06-24" @default.
- W2022383654 creator A5011483174 @default.
- W2022383654 creator A5012472887 @default.
- W2022383654 creator A5013706869 @default.
- W2022383654 creator A5034655250 @default.
- W2022383654 creator A5047066666 @default.
- W2022383654 date "1990-07-01" @default.
- W2022383654 modified "2023-09-24" @default.
- W2022383654 title "Intra-cerebral ventricular infusion of 5-IODO-2-deoxyuridine (IUDR) as a radiosensitizer in the treatment of a rat glioma" @default.
- W2022383654 cites W1526596922 @default.
- W2022383654 cites W15505271 @default.
- W2022383654 cites W1748218710 @default.
- W2022383654 cites W1964067380 @default.
- W2022383654 cites W1971923846 @default.
- W2022383654 cites W2017850071 @default.
- W2022383654 cites W2039831303 @default.
- W2022383654 cites W2065343709 @default.
- W2022383654 cites W2072427334 @default.
- W2022383654 cites W2082447949 @default.
- W2022383654 cites W2135188101 @default.
- W2022383654 cites W2165695298 @default.
- W2022383654 doi "https://doi.org/10.1016/0360-3016(90)90138-a" @default.
- W2022383654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2380099" @default.
- W2022383654 hasPublicationYear "1990" @default.
- W2022383654 type Work @default.
- W2022383654 sameAs 2022383654 @default.
- W2022383654 citedByCount "11" @default.
- W2022383654 countsByYear W20223836542014 @default.
- W2022383654 countsByYear W20223836542020 @default.
- W2022383654 crossrefType "journal-article" @default.
- W2022383654 hasAuthorship W2022383654A5011483174 @default.
- W2022383654 hasAuthorship W2022383654A5012472887 @default.
- W2022383654 hasAuthorship W2022383654A5013706869 @default.
- W2022383654 hasAuthorship W2022383654A5034655250 @default.
- W2022383654 hasAuthorship W2022383654A5047066666 @default.
- W2022383654 hasConcept C126322002 @default.
- W2022383654 hasConcept C126894567 @default.
- W2022383654 hasConcept C141071460 @default.
- W2022383654 hasConcept C2776428644 @default.
- W2022383654 hasConcept C2776473159 @default.
- W2022383654 hasConcept C2777111502 @default.
- W2022383654 hasConcept C2778227246 @default.
- W2022383654 hasConcept C2778921608 @default.
- W2022383654 hasConcept C2781171461 @default.
- W2022383654 hasConcept C2989005 @default.
- W2022383654 hasConcept C502942594 @default.
- W2022383654 hasConcept C509974204 @default.
- W2022383654 hasConcept C54355233 @default.
- W2022383654 hasConcept C552990157 @default.
- W2022383654 hasConcept C71924100 @default.
- W2022383654 hasConcept C86803240 @default.
- W2022383654 hasConceptScore W2022383654C126322002 @default.
- W2022383654 hasConceptScore W2022383654C126894567 @default.
- W2022383654 hasConceptScore W2022383654C141071460 @default.
- W2022383654 hasConceptScore W2022383654C2776428644 @default.
- W2022383654 hasConceptScore W2022383654C2776473159 @default.
- W2022383654 hasConceptScore W2022383654C2777111502 @default.
- W2022383654 hasConceptScore W2022383654C2778227246 @default.
- W2022383654 hasConceptScore W2022383654C2778921608 @default.
- W2022383654 hasConceptScore W2022383654C2781171461 @default.
- W2022383654 hasConceptScore W2022383654C2989005 @default.
- W2022383654 hasConceptScore W2022383654C502942594 @default.
- W2022383654 hasConceptScore W2022383654C509974204 @default.
- W2022383654 hasConceptScore W2022383654C54355233 @default.
- W2022383654 hasConceptScore W2022383654C552990157 @default.
- W2022383654 hasConceptScore W2022383654C71924100 @default.
- W2022383654 hasConceptScore W2022383654C86803240 @default.
- W2022383654 hasIssue "1" @default.
- W2022383654 hasLocation W20223836541 @default.
- W2022383654 hasLocation W20223836542 @default.
- W2022383654 hasOpenAccess W2022383654 @default.
- W2022383654 hasPrimaryLocation W20223836541 @default.
- W2022383654 hasRelatedWork W1601199866 @default.
- W2022383654 hasRelatedWork W2022383654 @default.
- W2022383654 hasRelatedWork W2082265821 @default.
- W2022383654 hasRelatedWork W2135188101 @default.
- W2022383654 hasRelatedWork W2373000442 @default.
- W2022383654 hasRelatedWork W2466942466 @default.
- W2022383654 hasRelatedWork W2729161207 @default.
- W2022383654 hasRelatedWork W2972838515 @default.
- W2022383654 hasRelatedWork W3030875851 @default.
- W2022383654 hasRelatedWork W3137087570 @default.
- W2022383654 hasVolume "19" @default.
- W2022383654 isParatext "false" @default.
- W2022383654 isRetracted "false" @default.
- W2022383654 magId "2022383654" @default.
- W2022383654 workType "article" @default.