FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022384403> ?p ?o ?g. }

• W2022384403 endingPage "37" @default.
• W2022384403 startingPage "31" @default.
• W2022384403 abstract "Identification of molecular alterations in biological fluids has been proposed as a powerful tool for cancer diagnosis. The purpose of this study was to identify cells that carry chromosomal alterations indicative of malignancy-specifically, gains in the loci 5p15.2 (D5S23, D5S721), 6p11 approximately q11, 7p12 (EGFR), and 8q24.12 approximately q24.13 (MYC)-for the detection of lung cancer using induced sputum. The overall sensitivity of the multicolor fluorescence in situ hybridization (FISH) assay from 52 lung cancer patients was 71% and the specificity was 100% (15 of 15). The most frequently detected gains were at 7p12 (EGFR) in 17 of 24 completely resectable early-stage (II+IIIA) non-small cell lung cancers (NSCLC) (71%). There was a statistically significant increase in the proportion of cases with gains of EGFR in squamous cell carcinomas (SCC), compared with adenocarcinomas (AC) (82 vs. 43%, respectively; P = 0.017), and a higher average EGFR gene copy number in the SCCs than in the ACs (5.04 vs. 3.78, respectively; P = 0.013) in 41 NSCLCs. Conversely, a gain at the 6p11 approximately q11 and 8q24.12 approximately q24.13 (MYC) regions appears to have a higher frequency of gain in the ACs (71 and 86%, respectively) than in the SCCs (48 and 56%, respectively). The results of this study showed the potential utility of the LAVysion FISH assay for the detection of lung cancer by a noninvasive technique based on the analysis of genetic alterations of induced sputum. Defining abnormalities in sputum specimens as FISH aneusomy may be a possible diagnostic method for the early detection of lung cancer in screening of high-risk populations and monitoring for recurrence." @default.
• W2022384403 created "2016-06-24" @default.
• W2022384403 creator A5025033424 @default.
• W2022384403 creator A5028455273 @default.
• W2022384403 creator A5064211577 @default.
• W2022384403 creator A5069512485 @default.
• W2022384403 creator A5083240027 @default.
• W2022384403 date "2008-07-01" @default.
• W2022384403 modified "2023-09-25" @default.
• W2022384403 title "Gain of the EGFR gene located on 7p12 is a frequent and early event in squamous cell carcinoma of the lung" @default.
• W2022384403 cites W1536563709 @default.
• W2022384403 cites W1978860349 @default.
• W2022384403 cites W1983523103 @default.
• W2022384403 cites W2000771104 @default.
• W2022384403 cites W2016471266 @default.
• W2022384403 cites W2024438850 @default.
• W2022384403 cites W2040843098 @default.
• W2022384403 cites W2048022218 @default.
• W2022384403 cites W2050105240 @default.
• W2022384403 cites W2064047613 @default.
• W2022384403 cites W2072363520 @default.
• W2022384403 cites W2082483504 @default.
• W2022384403 cites W2105101256 @default.
• W2022384403 cites W2114060414 @default.
• W2022384403 cites W2117819670 @default.
• W2022384403 cites W2120842104 @default.
• W2022384403 cites W2126560850 @default.
• W2022384403 cites W2132186502 @default.
• W2022384403 cites W2138604360 @default.
• W2022384403 cites W2145909626 @default.
• W2022384403 cites W2157709503 @default.
• W2022384403 cites W2166712337 @default.
• W2022384403 cites W4318470552 @default.
• W2022384403 doi "https://doi.org/10.1016/j.cancergencyto.2008.03.002" @default.
• W2022384403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18558286" @default.
• W2022384403 hasPublicationYear "2008" @default.
• W2022384403 type Work @default.
• W2022384403 sameAs 2022384403 @default.
• W2022384403 citedByCount "17" @default.
• W2022384403 countsByYear W20223844032012 @default.
• W2022384403 countsByYear W20223844032015 @default.
• W2022384403 countsByYear W20223844032016 @default.
• W2022384403 countsByYear W20223844032017 @default.
• W2022384403 countsByYear W20223844032020 @default.
• W2022384403 countsByYear W20223844032022 @default.
• W2022384403 crossrefType "journal-article" @default.
• W2022384403 hasAuthorship W2022384403A5025033424 @default.
• W2022384403 hasAuthorship W2022384403A5028455273 @default.
• W2022384403 hasAuthorship W2022384403A5064211577 @default.
• W2022384403 hasAuthorship W2022384403A5069512485 @default.
• W2022384403 hasAuthorship W2022384403A5083240027 @default.
• W2022384403 hasConcept C104317684 @default.
• W2022384403 hasConcept C121608353 @default.
• W2022384403 hasConcept C126322002 @default.
• W2022384403 hasConcept C142724271 @default.
• W2022384403 hasConcept C143998085 @default.
• W2022384403 hasConcept C146357865 @default.
• W2022384403 hasConcept C151730666 @default.
• W2022384403 hasConcept C2776256026 @default.
• W2022384403 hasConcept C2776301714 @default.
• W2022384403 hasConcept C2777542201 @default.
• W2022384403 hasConcept C2777546739 @default.
• W2022384403 hasConcept C2777714996 @default.
• W2022384403 hasConcept C2779399171 @default.
• W2022384403 hasConcept C2781069245 @default.
• W2022384403 hasConcept C2994491419 @default.
• W2022384403 hasConcept C30481170 @default.
• W2022384403 hasConcept C502942594 @default.
• W2022384403 hasConcept C54355233 @default.
• W2022384403 hasConcept C71924100 @default.
• W2022384403 hasConcept C7602840 @default.
• W2022384403 hasConcept C86803240 @default.
• W2022384403 hasConceptScore W2022384403C104317684 @default.
• W2022384403 hasConceptScore W2022384403C121608353 @default.
• W2022384403 hasConceptScore W2022384403C126322002 @default.
• W2022384403 hasConceptScore W2022384403C142724271 @default.
• W2022384403 hasConceptScore W2022384403C143998085 @default.
• W2022384403 hasConceptScore W2022384403C146357865 @default.
• W2022384403 hasConceptScore W2022384403C151730666 @default.
• W2022384403 hasConceptScore W2022384403C2776256026 @default.
• W2022384403 hasConceptScore W2022384403C2776301714 @default.
• W2022384403 hasConceptScore W2022384403C2777542201 @default.
• W2022384403 hasConceptScore W2022384403C2777546739 @default.
• W2022384403 hasConceptScore W2022384403C2777714996 @default.
• W2022384403 hasConceptScore W2022384403C2779399171 @default.
• W2022384403 hasConceptScore W2022384403C2781069245 @default.
• W2022384403 hasConceptScore W2022384403C2994491419 @default.
• W2022384403 hasConceptScore W2022384403C30481170 @default.
• W2022384403 hasConceptScore W2022384403C502942594 @default.
• W2022384403 hasConceptScore W2022384403C54355233 @default.
• W2022384403 hasConceptScore W2022384403C71924100 @default.
• W2022384403 hasConceptScore W2022384403C7602840 @default.
• W2022384403 hasConceptScore W2022384403C86803240 @default.
• W2022384403 hasIssue "1" @default.
• W2022384403 hasLocation W20223844031 @default.
• W2022384403 hasLocation W20223844032 @default.
• W2022384403 hasOpenAccess W2022384403 @default.
• W2022384403 hasPrimaryLocation W20223844031 @default.

• next