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- W2022385423 abstract "Although the hereditary information is encoded in the primary sequence of the genetic material, much of the regulatory information of DNA is hidden in its topology and geometry in the cell. DNA supercoiling and knotting are important for DNA packaging within all cells, however this impairs the well behavior of multiples cellular processes such as replication and transcription, which involve helical winding, strand separation, and movement along the DNA. The steric and topological problems associated with supercoiling can be studied with numerous different tools among which scanning probe microscopy is a very promising one because of its capability to image on line and with a high resolution, biological samples in nearly physiological conditions.In this work we studied the way enzymes and drugs interact with DNA molecules by using Atomic Force Microscopy (AFM). Particularly, we have centered our studies on human type II DNA topoisomerases (Top2), which are essential and ubiquitous enzymes that perform important intracellular roles in chromosome condensation and segregation, and in regulating DNA supercoiling. We will present real time movies showing how the Top2 relaxes DNA. In addition we will present AFM images showing the way DNA changes its topology after being exposed to intercalating agents. We hope that this new methodology will unveil some of the still poorly known DNA-proteins and drugs interaction." @default.
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- W2022385423 date "2011-02-01" @default.
- W2022385423 modified "2023-09-28" @default.
- W2022385423 title "Manipulation of Single Knotted DNA Molecules with Topoisomerase II by using Atomic Force Microscopy" @default.
- W2022385423 doi "https://doi.org/10.1016/j.bpj.2010.12.1109" @default.
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