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- W2022385680 abstract "Suitable substituted phthalocyanines are promising and widely investigated photosensitizers (PS) for the photodynamic therapy of cancer (PDT). However, selective accumulation of the PSs in tumor tissues, avoiding contamination of healthy tissues, is still an unsolved central problem. We present first results on the synthesis of new biotinylated phthalocyanines as potentially selective photosensitizers when applied in a polyphasic tumor targeting (tumor cell plus first step: biotinylated/monoclonal antibody, second step: streptavidin, and third step: biotinylated PS). The binding and the photodynamic activity of biotinylated PS in this three step model is shown in tumor cell lines." @default.
- W2022385680 created "2016-06-24" @default.
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- W2022385680 date "1997-12-29" @default.
- W2022385680 modified "2023-09-27" @default.
- W2022385680 title "<title>New biotinylated phthalocyanines for the photodynamic therapy of cancer</title>" @default.
- W2022385680 doi "https://doi.org/10.1117/12.297819" @default.
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