Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022385814> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2022385814 abstract "Although the hippocampus is processing temporal and spatial information in particular context, the encoding rule creating memory is completely unknown. To examine the mechanism, we trained rats on an inhibitory avoidance (IA) task, a hippocampus-dependent rapid one-trial contextual learning paradigm. By combining Herpes virus-mediated in vivo gene delivery with in vitro patch-clamp recordings, I reported contextual learning drives GluR1-containing AMPA receptors into CA3-CA1 synapses. The molecular event is required for contextual memory, since bilateral expression of delivery blocker in CA1 successfully blocked IA learning. Moreover, I found a logarithmic correlation between the number of delivery blocking cells and learning performance. Considering that one all-or-none device can process 1-bit of data per clock (Nobert Wiener 1961), the logarithmic correlation may provides evidence that CA1 neurons transmit essential data of contextual information. Further, I recently reported critical role of acetylcholine as an intrinsic trigger of learning-dependent synaptic plasticity. IA training induced ACh release in CA1 that strengthened not only AMPA receptor-mediated excitatory synapses, but also GABA A receptor-mediated inhibitory synapses on each CA1 neuron. More importantly, IA-trained rats showed individually different excitatory and inhibitory synaptic inputs with wide variation on each CA1 neuron. Here I propose a new hypothesis that the diversity of synaptic inputs on CA1 neurons may depict cell-specific outputs processing experienced episodes after training." @default.
- W2022385814 created "2016-06-24" @default.
- W2022385814 creator A5084170860 @default.
- W2022385814 date "2015-01-01" @default.
- W2022385814 modified "2023-09-27" @default.
- W2022385814 title "Contextual Learning Requires Functional Diversity at Excitatory and Inhibitory Synapses onto CA1 Pyramidal Neurons" @default.
- W2022385814 cites W1544397829 @default.
- W2022385814 cites W1658884838 @default.
- W2022385814 cites W1968023011 @default.
- W2022385814 cites W1970616082 @default.
- W2022385814 cites W1973669054 @default.
- W2022385814 cites W1974791004 @default.
- W2022385814 cites W1983106433 @default.
- W2022385814 cites W1985582399 @default.
- W2022385814 cites W1989034785 @default.
- W2022385814 cites W1994711780 @default.
- W2022385814 cites W2009782005 @default.
- W2022385814 cites W2014642981 @default.
- W2022385814 cites W2014886338 @default.
- W2022385814 cites W2018434736 @default.
- W2022385814 cites W2021280501 @default.
- W2022385814 cites W2025801062 @default.
- W2022385814 cites W2027006706 @default.
- W2022385814 cites W2032118090 @default.
- W2022385814 cites W2037530651 @default.
- W2022385814 cites W2037685778 @default.
- W2022385814 cites W2041359982 @default.
- W2022385814 cites W2042956033 @default.
- W2022385814 cites W2048904401 @default.
- W2022385814 cites W2050485762 @default.
- W2022385814 cites W2052809998 @default.
- W2022385814 cites W2067318929 @default.
- W2022385814 cites W2068857365 @default.
- W2022385814 cites W2074620251 @default.
- W2022385814 cites W2075236815 @default.
- W2022385814 cites W2078526156 @default.
- W2022385814 cites W2087914502 @default.
- W2022385814 cites W2089178573 @default.
- W2022385814 cites W2089771587 @default.
- W2022385814 cites W2093116784 @default.
- W2022385814 cites W2095484045 @default.
- W2022385814 cites W2096709796 @default.
- W2022385814 cites W2107820540 @default.
- W2022385814 cites W2108794414 @default.
- W2022385814 cites W2109645417 @default.
- W2022385814 cites W2112522119 @default.
- W2022385814 cites W2139584541 @default.
- W2022385814 cites W2165840219 @default.
- W2022385814 cites W2336126697 @default.
- W2022385814 cites W2410446460 @default.
- W2022385814 cites W3146846001 @default.
- W2022385814 doi "https://doi.org/10.3934/neuroscience.2015.1.7" @default.
- W2022385814 hasPublicationYear "2015" @default.
- W2022385814 type Work @default.
- W2022385814 sameAs 2022385814 @default.
- W2022385814 citedByCount "1" @default.
- W2022385814 countsByYear W20223858142015 @default.
- W2022385814 crossrefType "journal-article" @default.
- W2022385814 hasAuthorship W2022385814A5084170860 @default.
- W2022385814 hasBestOaLocation W20223858141 @default.
- W2022385814 hasConcept C112592302 @default.
- W2022385814 hasConcept C15744967 @default.
- W2022385814 hasConcept C169760540 @default.
- W2022385814 hasConcept C17077164 @default.
- W2022385814 hasConcept C86803240 @default.
- W2022385814 hasConceptScore W2022385814C112592302 @default.
- W2022385814 hasConceptScore W2022385814C15744967 @default.
- W2022385814 hasConceptScore W2022385814C169760540 @default.
- W2022385814 hasConceptScore W2022385814C17077164 @default.
- W2022385814 hasConceptScore W2022385814C86803240 @default.
- W2022385814 hasLocation W20223858141 @default.
- W2022385814 hasLocation W20223858142 @default.
- W2022385814 hasOpenAccess W2022385814 @default.
- W2022385814 hasPrimaryLocation W20223858141 @default.
- W2022385814 hasRelatedWork W1998768495 @default.
- W2022385814 hasRelatedWork W2044962914 @default.
- W2022385814 hasRelatedWork W2075385578 @default.
- W2022385814 hasRelatedWork W2254573027 @default.
- W2022385814 hasRelatedWork W2287764147 @default.
- W2022385814 hasRelatedWork W2751847892 @default.
- W2022385814 hasRelatedWork W2975717374 @default.
- W2022385814 hasRelatedWork W3006582284 @default.
- W2022385814 hasRelatedWork W3148410686 @default.
- W2022385814 hasRelatedWork W4212915683 @default.
- W2022385814 isParatext "false" @default.
- W2022385814 isRetracted "false" @default.
- W2022385814 magId "2022385814" @default.
- W2022385814 workType "article" @default.