Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022386082> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2022386082 endingPage "227" @default.
- W2022386082 startingPage "224" @default.
- W2022386082 abstract "A rapid and sensitive HPLC/MS/MS method was developed and validated for simultaneous determination of tinidazole, dyclonine and chlorhexidine, the three main components of a film-forming solution, in rat plasma. The plasma samples were pretreated by solid phase extraction (SPE) method. Separation was achieved on a Phenomenex Gemini C(18) column (50 mm × 2.0 mm, 5 μm) using an isocratic mobile phase system composed of methanol-ammonium formate (10 mM)-formic acid (56:44:0.2, v/v/v) (pH 3.5) at a flow rate of 0.2 mL/min. Analytes were determined by tandem mass spectrometry with electrospray positive ionization and multiple-reaction monitoring (MRM) mode. The monitoring ions were (m/z) 247.4 → (m/z) 81.9 for tinidazole, (m/z) 290.1 → (m/z) 97.8 for dyclonine, (m/z) 505.0 → (m/z) 335.3 for chlorhexidine and (m/z) 282.1 → (m/z) 212.0 for phentolamine (internal standard). The calibration curves were linear in the range of 2-1000 ng/mL for the three components. The precision and accuracy of the method were well within the generally accepted criteria for biomedical analysis. It has been successfully applied to the pharmacokinetic research of a film-forming solution in rat." @default.
- W2022386082 created "2016-06-24" @default.
- W2022386082 creator A5026959354 @default.
- W2022386082 creator A5031000779 @default.
- W2022386082 creator A5045942733 @default.
- W2022386082 creator A5085304310 @default.
- W2022386082 date "2012-03-01" @default.
- W2022386082 modified "2023-09-26" @default.
- W2022386082 title "Development of a HPLC/MS/MS method for simultaneous determination of tinidazole, dyclonine and chlorhexidine in rat plasma and its application in the pharmacokinetic research of a film-forming solution" @default.
- W2022386082 cites W1978922943 @default.
- W2022386082 cites W2000167914 @default.
- W2022386082 cites W2019919776 @default.
- W2022386082 cites W2050226999 @default.
- W2022386082 cites W2163499901 @default.
- W2022386082 doi "https://doi.org/10.1016/j.jpba.2012.01.009" @default.
- W2022386082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22305084" @default.
- W2022386082 hasPublicationYear "2012" @default.
- W2022386082 type Work @default.
- W2022386082 sameAs 2022386082 @default.
- W2022386082 citedByCount "12" @default.
- W2022386082 countsByYear W20223860822013 @default.
- W2022386082 countsByYear W20223860822017 @default.
- W2022386082 countsByYear W20223860822020 @default.
- W2022386082 countsByYear W20223860822022 @default.
- W2022386082 countsByYear W20223860822023 @default.
- W2022386082 crossrefType "journal-article" @default.
- W2022386082 hasAuthorship W2022386082A5026959354 @default.
- W2022386082 hasAuthorship W2022386082A5031000779 @default.
- W2022386082 hasAuthorship W2022386082A5045942733 @default.
- W2022386082 hasAuthorship W2022386082A5085304310 @default.
- W2022386082 hasConcept C112705442 @default.
- W2022386082 hasConcept C113196181 @default.
- W2022386082 hasConcept C119128265 @default.
- W2022386082 hasConcept C126322002 @default.
- W2022386082 hasConcept C162356407 @default.
- W2022386082 hasConcept C185592680 @default.
- W2022386082 hasConcept C23531484 @default.
- W2022386082 hasConcept C2775986502 @default.
- W2022386082 hasConcept C2777379063 @default.
- W2022386082 hasConcept C2777396551 @default.
- W2022386082 hasConcept C2780626017 @default.
- W2022386082 hasConcept C31827203 @default.
- W2022386082 hasConcept C40684141 @default.
- W2022386082 hasConcept C43617362 @default.
- W2022386082 hasConcept C4725764 @default.
- W2022386082 hasConcept C501593827 @default.
- W2022386082 hasConcept C55493867 @default.
- W2022386082 hasConcept C71043704 @default.
- W2022386082 hasConcept C71924100 @default.
- W2022386082 hasConcept C81426234 @default.
- W2022386082 hasConceptScore W2022386082C112705442 @default.
- W2022386082 hasConceptScore W2022386082C113196181 @default.
- W2022386082 hasConceptScore W2022386082C119128265 @default.
- W2022386082 hasConceptScore W2022386082C126322002 @default.
- W2022386082 hasConceptScore W2022386082C162356407 @default.
- W2022386082 hasConceptScore W2022386082C185592680 @default.
- W2022386082 hasConceptScore W2022386082C23531484 @default.
- W2022386082 hasConceptScore W2022386082C2775986502 @default.
- W2022386082 hasConceptScore W2022386082C2777379063 @default.
- W2022386082 hasConceptScore W2022386082C2777396551 @default.
- W2022386082 hasConceptScore W2022386082C2780626017 @default.
- W2022386082 hasConceptScore W2022386082C31827203 @default.
- W2022386082 hasConceptScore W2022386082C40684141 @default.
- W2022386082 hasConceptScore W2022386082C43617362 @default.
- W2022386082 hasConceptScore W2022386082C4725764 @default.
- W2022386082 hasConceptScore W2022386082C501593827 @default.
- W2022386082 hasConceptScore W2022386082C55493867 @default.
- W2022386082 hasConceptScore W2022386082C71043704 @default.
- W2022386082 hasConceptScore W2022386082C71924100 @default.
- W2022386082 hasConceptScore W2022386082C81426234 @default.
- W2022386082 hasLocation W20223860821 @default.
- W2022386082 hasLocation W20223860822 @default.
- W2022386082 hasOpenAccess W2022386082 @default.
- W2022386082 hasPrimaryLocation W20223860821 @default.
- W2022386082 hasRelatedWork W1277187992 @default.
- W2022386082 hasRelatedWork W1992561179 @default.
- W2022386082 hasRelatedWork W2001353325 @default.
- W2022386082 hasRelatedWork W2004432487 @default.
- W2022386082 hasRelatedWork W2029274763 @default.
- W2022386082 hasRelatedWork W2035757008 @default.
- W2022386082 hasRelatedWork W2082766191 @default.
- W2022386082 hasRelatedWork W2353675607 @default.
- W2022386082 hasRelatedWork W2964434578 @default.
- W2022386082 hasRelatedWork W3202079152 @default.
- W2022386082 hasVolume "62" @default.
- W2022386082 isParatext "false" @default.
- W2022386082 isRetracted "false" @default.
- W2022386082 magId "2022386082" @default.
- W2022386082 workType "article" @default.