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- W2022386478 abstract "Abstract Phlorizin ( 1 ) was anaerobically incubated with human intestinal bacteria and five biotransformation products ( 2 – 6 ) were obtained. Their structures were elucidated as phloretin ( 2 ), phloroglucinol ( 3 ), phloretic acid ( 4 ), 2,3,4-trihydroxybenzenepropanoic acid ( 5 ), and phloretic acid methyl ester ( 6 ) on the basis of their spectroscopic data. Using high-performance liquid chromatography equipped with a diode array detector, chromatographic separation of 1 – 4 was performed on an analytical C 18 column. The time course of the biotransformation was studied to probe into the biotransformation mechanism of 1 by human intestinal flora. The abilities of isolated strains to transform 1 were also investigated in order to find an optimal transformation strain. In addition, the inhibitory activity of parent compound 1 and its three main biotransformation products 2 – 4 on mushroom tyrosinase was estimated. The result showed that 2 has better inhibitory effect on tyrosinase activity than 1 ." @default.
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- W2022386478 date "2012-05-01" @default.
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- W2022386478 title "Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity" @default.
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- W2022386478 doi "https://doi.org/10.1016/j.foodchem.2011.11.071" @default.
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