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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022386980> ?p ?o ?g. }

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• W2022386980 startingPage "130" @default.
• W2022386980 abstract "The mammalian ATP/ADP translocator isoform-2 (ANT2) gene is growth-activated. Regulation of the gene appears to involve Sp1, as an essential activator, and a suppressor through an Sp1 core element next to the transcription start. We show here that the proximal promoter also binds AP-2 strongly and specifically to two sites, one of which overlaps the Sp1 proximal suppressor site. AP-2 binds with an affinity of 10 to15 fold higher than that of Sp1. AP-2 alone does not alter the ANT2 promoter activity in transfected SL2 cells, but enhances the Sp1-dependent activation of the promoter several fold. Enhancement by AP-2 is observed only when Sp1 is limiting for transcription activation. These data suggest that the cellular AP-2/Sp1 ratio might influence ANT2 expression in developing or differentiating cells." @default.
• W2022386980 created "2016-06-24" @default.
• W2022386980 creator A5017968623 @default.
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• W2022386980 date "1999-07-01" @default.
• W2022386980 modified "2023-10-17" @default.
• W2022386980 title "1AP-2 Enhances Spl-Dependent Activation of the Growth-Regulated Human ATP/ADP Translocator" @default.
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• W2022386980 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a022413" @default.
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