Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022388431> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2022388431 endingPage "463" @default.
- W2022388431 startingPage "458" @default.
- W2022388431 abstract "The main cyclooxygenase-dependent arachidonic acid derivatives produced by monocytes and macrophages have been shown to be thromboxane A2 and prostaglandin E2. The immunomodulatory effects of thromboxane A2 were examined using a specific thromboxane synthase inhibitor (dazoxiben), a thromboxane A2 analog (U46619), and a thromboxane A2 receptor blocker (BM13.177). Dazoxiben inhibited lymphocyte proliferation in response to mitogens (PHA and OKT3), but also reoriented cyclic endoperoxide metabolism towards the production of prostaglandin E2. Prostaglandin E2 has been shown previously to inhibit mitogen-induced lymphocyte proliferation. U46619, a stable thromboxane A2 analog, slightly enhanced lymphocyte responses to mitogens in the presence of dazoxiben and in the presence of a cyclooxygenase inhibitor (indomethacin). This occurred at concentrations of U46619 which are probably supraphysiological in view of the short half-life of natural thromboxane A2. Finally, the thromboxane A2 receptor blocker BM13.177 did not have any effect on mitogen-induced lymphocyte proliferation. It is concluded that thromboxane A2 has no or minimal modulatory effects on lymphocyte proliferative responses to mitogens and that the effect of thromboxane A2 synthase inhibition is rather due to reorientation of cyclic endoperoxide metabolism, resulting in increased prostaglandin E2 production." @default.
- W2022388431 created "2016-06-24" @default.
- W2022388431 creator A5016803288 @default.
- W2022388431 creator A5022448402 @default.
- W2022388431 creator A5036180073 @default.
- W2022388431 creator A5050892519 @default.
- W2022388431 date "1985-02-01" @default.
- W2022388431 modified "2023-09-26" @default.
- W2022388431 title "Effects of thromboxane A2 on lymphocyte proliferation" @default.
- W2022388431 cites W1549366189 @default.
- W2022388431 cites W1595212852 @default.
- W2022388431 cites W1963860018 @default.
- W2022388431 cites W2006813468 @default.
- W2022388431 cites W2013482261 @default.
- W2022388431 cites W2015211989 @default.
- W2022388431 cites W2021282950 @default.
- W2022388431 cites W2054262691 @default.
- W2022388431 cites W2054909672 @default.
- W2022388431 cites W2061169185 @default.
- W2022388431 cites W2151129289 @default.
- W2022388431 cites W2155027494 @default.
- W2022388431 cites W4321835896 @default.
- W2022388431 doi "https://doi.org/10.1016/0008-8749(85)90210-2" @default.
- W2022388431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3155656" @default.
- W2022388431 hasPublicationYear "1985" @default.
- W2022388431 type Work @default.
- W2022388431 sameAs 2022388431 @default.
- W2022388431 citedByCount "31" @default.
- W2022388431 countsByYear W20223884312013 @default.
- W2022388431 countsByYear W20223884312015 @default.
- W2022388431 countsByYear W20223884312019 @default.
- W2022388431 countsByYear W20223884312020 @default.
- W2022388431 crossrefType "journal-article" @default.
- W2022388431 hasAuthorship W2022388431A5016803288 @default.
- W2022388431 hasAuthorship W2022388431A5022448402 @default.
- W2022388431 hasAuthorship W2022388431A5036180073 @default.
- W2022388431 hasAuthorship W2022388431A5050892519 @default.
- W2022388431 hasConcept C126322002 @default.
- W2022388431 hasConcept C134018914 @default.
- W2022388431 hasConcept C170493617 @default.
- W2022388431 hasConcept C173202427 @default.
- W2022388431 hasConcept C181199279 @default.
- W2022388431 hasConcept C203014093 @default.
- W2022388431 hasConcept C2776785769 @default.
- W2022388431 hasConcept C2777198256 @default.
- W2022388431 hasConcept C2777761686 @default.
- W2022388431 hasConcept C2777956040 @default.
- W2022388431 hasConcept C2779689624 @default.
- W2022388431 hasConcept C2780664492 @default.
- W2022388431 hasConcept C2781024287 @default.
- W2022388431 hasConcept C2781080829 @default.
- W2022388431 hasConcept C51603380 @default.
- W2022388431 hasConcept C55493867 @default.
- W2022388431 hasConcept C71924100 @default.
- W2022388431 hasConcept C86803240 @default.
- W2022388431 hasConcept C89560881 @default.
- W2022388431 hasConceptScore W2022388431C126322002 @default.
- W2022388431 hasConceptScore W2022388431C134018914 @default.
- W2022388431 hasConceptScore W2022388431C170493617 @default.
- W2022388431 hasConceptScore W2022388431C173202427 @default.
- W2022388431 hasConceptScore W2022388431C181199279 @default.
- W2022388431 hasConceptScore W2022388431C203014093 @default.
- W2022388431 hasConceptScore W2022388431C2776785769 @default.
- W2022388431 hasConceptScore W2022388431C2777198256 @default.
- W2022388431 hasConceptScore W2022388431C2777761686 @default.
- W2022388431 hasConceptScore W2022388431C2777956040 @default.
- W2022388431 hasConceptScore W2022388431C2779689624 @default.
- W2022388431 hasConceptScore W2022388431C2780664492 @default.
- W2022388431 hasConceptScore W2022388431C2781024287 @default.
- W2022388431 hasConceptScore W2022388431C2781080829 @default.
- W2022388431 hasConceptScore W2022388431C51603380 @default.
- W2022388431 hasConceptScore W2022388431C55493867 @default.
- W2022388431 hasConceptScore W2022388431C71924100 @default.
- W2022388431 hasConceptScore W2022388431C86803240 @default.
- W2022388431 hasConceptScore W2022388431C89560881 @default.
- W2022388431 hasIssue "2" @default.
- W2022388431 hasLocation W20223884311 @default.
- W2022388431 hasLocation W20223884312 @default.
- W2022388431 hasOpenAccess W2022388431 @default.
- W2022388431 hasPrimaryLocation W20223884311 @default.
- W2022388431 hasRelatedWork W1996409233 @default.
- W2022388431 hasRelatedWork W2004298214 @default.
- W2022388431 hasRelatedWork W2021126401 @default.
- W2022388431 hasRelatedWork W2022388431 @default.
- W2022388431 hasRelatedWork W2040455391 @default.
- W2022388431 hasRelatedWork W2074285049 @default.
- W2022388431 hasRelatedWork W2086936440 @default.
- W2022388431 hasRelatedWork W2416606623 @default.
- W2022388431 hasRelatedWork W2951333278 @default.
- W2022388431 hasRelatedWork W98406121 @default.
- W2022388431 hasVolume "90" @default.
- W2022388431 isParatext "false" @default.
- W2022388431 isRetracted "false" @default.
- W2022388431 magId "2022388431" @default.
- W2022388431 workType "article" @default.