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- W2022388868 endingPage "1733" @default.
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- W2022388868 abstract "A combination of pharmacological and genetic studies in mice confirmed that the Y1 and Y5 receptors mediate the potent orexigenic actions of exogenous NPY. Although the physiological role of NPY in causing obesity is less clear, potent and selective antagonists of both Y1 and Y5 have been developed. Some of the NPY antagonists have suitable pharmokinetic (PK) properties that allowed them to be evaluated in various rodent models of obesity. Several different Y1 and Y5 antagonists cause weight loss in rodent models, though confirmation that these effects are mechanism based has been limited. One Y5 antagonist, MK-0557 was evaluated in a 1-yr clinical trial and found to cause modest weight loss. Optimal NPY antagonist therapeutics for obesity may require blockade of both the Y1 and Y5 receptors. Keywords: Neuropeptide Y, Y1, Y5, receptor, antagonist, obesity" @default.
- W2022388868 created "2016-06-24" @default.
- W2022388868 creator A5067821112 @default.
- W2022388868 date "2007-09-01" @default.
- W2022388868 modified "2023-09-25" @default.
- W2022388868 title "NPY Y1 and Y5 Receptor Selective Antagonists as Anti-Obesity Drugs" @default.
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