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- W2022394145 abstract "[11C]Methyl triflate was compared with [11C]methyl iodide as a labelled precursor in the synthesis of PET radioligands through 11C-methylation of amide and thiol functions. [11C]NMSP, [11C]flumazenil and [11C]methionine were prepared in 50–75% radiochemical yields using smaller amounts of precursors, shorter reaction times and lower reaction temperatures than previously used when these compounds were prepared from [11C]methyl iodide. By minimizing the amount of base used in the synthesis of [11C]methionine from [11C]methyl triflate and L-homocysteine thiolactone in water a lower amount (1–2%) of D-[11C]methionine was obtained. The results demonstrate that [11C]methyl triflate is compatible with low concentrations of aqueous sodium hydroxide, which enable its use in the preparation of PET radioligands through 11C-methylation of amide and thiol functions. © 1998 John Wiley & Sons, Ltd." @default.
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- W2022394145 title "Methylation of amide and thiol functions with [11C]methyl triflate, as exemplified by [11C]NMSP[11C]flumazenil and [11C]methionine" @default.
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- W2022394145 doi "https://doi.org/10.1002/(sici)1099-1344(1998090)41:9<831::aid-jlcr129>3.0.co;2-e" @default.
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