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- W2022397757 abstract "Using the mixed leukocyte culture (MLC) reaction as a model system for the generation of cytotoxic effector lymphocytes, we have examined changes which occur in recognition-binding function during T cell sensitization. Properties of recognition-binding units on normal and immune T lymphocytes were assessed through the ability of T cells to bind to specific cellular immunoadsorbants at various stages of in vitro sensitization. While antigen-specific recognition-binding function was readily detected on fully cytotoxic effector cells, we were unable to detect functionally specific binding of unsensitized lymphocytes to cellular immunoadsorbants. The ability of cells undergoing sensitization in MLC to bind specifically to target cell monolayers appeared congruent in time with cytotoxic function. These results suggest that a fundamental membrane-associated change occurring during T cell sensitization may be the development of a strong and specific target-cell binding function." @default.
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- W2022397757 date "1974-04-01" @default.
- W2022397757 modified "2023-10-16" @default.
- W2022397757 title "Functional characteristics of T cell receptors during sensitization against histocompatibility antigens in vitro" @default.
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- W2022397757 doi "https://doi.org/10.1016/0008-8749(74)90064-1" @default.
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