Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022400526> ?p ?o ?g. }
- W2022400526 endingPage "e1004905" @default.
- W2022400526 startingPage "e1004905" @default.
- W2022400526 abstract "Active DNA demethylation in plants occurs through base excision repair, beginning with removal of methylated cytosine by the ROS1/DME subfamily of 5-methylcytosine DNA glycosylases. Active DNA demethylation in animals requires the DNA glycosylase TDG or MBD4, which functions after oxidation or deamination of 5-methylcytosine, respectively. However, little is known about the steps following DNA glycosylase action in the active DNA demethylation pathways in plants and animals. We show here that the Arabidopsis APE1L protein has apurinic/apyrimidinic endonuclease activities and functions downstream of ROS1 and DME. APE1L and ROS1 interact in vitro and co-localize in vivo. Whole genome bisulfite sequencing of ape1l mutant plants revealed widespread alterations in DNA methylation. We show that the ape1l/zdp double mutant displays embryonic lethality. Notably, the ape1l+/−zdp−/− mutant shows a maternal-effect lethality phenotype. APE1L and the DNA phosphatase ZDP are required for FWA and MEA gene imprinting in the endosperm and are important for seed development. Thus, APE1L is a new component of the active DNA demethylation pathway and, together with ZDP, regulates gene imprinting in Arabidopsis." @default.
- W2022400526 created "2016-06-24" @default.
- W2022400526 creator A5015413405 @default.
- W2022400526 creator A5023550343 @default.
- W2022400526 creator A5042340196 @default.
- W2022400526 creator A5046403679 @default.
- W2022400526 creator A5049293054 @default.
- W2022400526 creator A5049593200 @default.
- W2022400526 creator A5055653250 @default.
- W2022400526 creator A5059849151 @default.
- W2022400526 creator A5060403738 @default.
- W2022400526 date "2015-01-08" @default.
- W2022400526 modified "2023-10-12" @default.
- W2022400526 title "An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in Arabidopsis" @default.
- W2022400526 cites W1965851786 @default.
- W2022400526 cites W1973640585 @default.
- W2022400526 cites W1979733539 @default.
- W2022400526 cites W1980815569 @default.
- W2022400526 cites W1982286076 @default.
- W2022400526 cites W1987227502 @default.
- W2022400526 cites W1987870439 @default.
- W2022400526 cites W2011303868 @default.
- W2022400526 cites W2018249152 @default.
- W2022400526 cites W2019630339 @default.
- W2022400526 cites W2026175443 @default.
- W2022400526 cites W2026343134 @default.
- W2022400526 cites W2031588835 @default.
- W2022400526 cites W2032843351 @default.
- W2022400526 cites W2034659295 @default.
- W2022400526 cites W2036848594 @default.
- W2022400526 cites W2058058399 @default.
- W2022400526 cites W2059979506 @default.
- W2022400526 cites W2062211740 @default.
- W2022400526 cites W2064489231 @default.
- W2022400526 cites W2079862188 @default.
- W2022400526 cites W2082679628 @default.
- W2022400526 cites W2089812281 @default.
- W2022400526 cites W2089832295 @default.
- W2022400526 cites W2090042982 @default.
- W2022400526 cites W2091601313 @default.
- W2022400526 cites W2101392500 @default.
- W2022400526 cites W2101920472 @default.
- W2022400526 cites W2111350536 @default.
- W2022400526 cites W2118211530 @default.
- W2022400526 cites W2128716096 @default.
- W2022400526 cites W2130535352 @default.
- W2022400526 cites W2134030532 @default.
- W2022400526 cites W2135640258 @default.
- W2022400526 cites W2141026227 @default.
- W2022400526 cites W2152477075 @default.
- W2022400526 cites W2155772493 @default.
- W2022400526 cites W2156241460 @default.
- W2022400526 cites W2156825952 @default.
- W2022400526 cites W2160046367 @default.
- W2022400526 cites W2160059106 @default.
- W2022400526 cites W2161227229 @default.
- W2022400526 cites W2170099595 @default.
- W2022400526 cites W2170828323 @default.
- W2022400526 doi "https://doi.org/10.1371/journal.pgen.1004905" @default.
- W2022400526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4287435" @default.
- W2022400526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25569774" @default.
- W2022400526 hasPublicationYear "2015" @default.
- W2022400526 type Work @default.
- W2022400526 sameAs 2022400526 @default.
- W2022400526 citedByCount "50" @default.
- W2022400526 countsByYear W20224005262015 @default.
- W2022400526 countsByYear W20224005262016 @default.
- W2022400526 countsByYear W20224005262017 @default.
- W2022400526 countsByYear W20224005262018 @default.
- W2022400526 countsByYear W20224005262019 @default.
- W2022400526 countsByYear W20224005262020 @default.
- W2022400526 countsByYear W20224005262021 @default.
- W2022400526 countsByYear W20224005262022 @default.
- W2022400526 countsByYear W20224005262023 @default.
- W2022400526 crossrefType "journal-article" @default.
- W2022400526 hasAuthorship W2022400526A5015413405 @default.
- W2022400526 hasAuthorship W2022400526A5023550343 @default.
- W2022400526 hasAuthorship W2022400526A5042340196 @default.
- W2022400526 hasAuthorship W2022400526A5046403679 @default.
- W2022400526 hasAuthorship W2022400526A5049293054 @default.
- W2022400526 hasAuthorship W2022400526A5049593200 @default.
- W2022400526 hasAuthorship W2022400526A5055653250 @default.
- W2022400526 hasAuthorship W2022400526A5059849151 @default.
- W2022400526 hasAuthorship W2022400526A5060403738 @default.
- W2022400526 hasBestOaLocation W20224005261 @default.
- W2022400526 hasConcept C104317684 @default.
- W2022400526 hasConcept C134935766 @default.
- W2022400526 hasConcept C150194340 @default.
- W2022400526 hasConcept C153911025 @default.
- W2022400526 hasConcept C16824249 @default.
- W2022400526 hasConcept C190727270 @default.
- W2022400526 hasConcept C192396546 @default.
- W2022400526 hasConcept C2775926025 @default.
- W2022400526 hasConcept C552990157 @default.
- W2022400526 hasConcept C55493867 @default.
- W2022400526 hasConcept C86803240 @default.
- W2022400526 hasConceptScore W2022400526C104317684 @default.
- W2022400526 hasConceptScore W2022400526C134935766 @default.