FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022405810> ?p ?o ?g. }

• W2022405810 endingPage "187" @default.
• W2022405810 startingPage "178" @default.
• W2022405810 abstract "Mice with targeted deletion of L-selectin gene (L-sel(-/-)) were used to investigate the role of adhesion molecule in immunologic responses following virus infection in the central nervous system (CNS). L-Sel(-/-) mice from a resistant H-2(b) genetic background and parental wild-type H-2(b) (C57BL/6) mice were infected with Theiler's murine encephalomyelitis virus (TMEV) intracerebrally and the kinetics of virus replication and infiltration of immune cells in the CNS determined. The levels of infectious TMEV, as measured by plaque assay at 3, 7, 14, and 28 days after infection were between 4 and 6 log(10) PFU of virus per gram of CNS tissues at days 3 and 7 post-infection, and then decreased to undetectable levels by day 14 after infection in both strains of mice. The L-sel(-/-) mice had decreased numbers of CD8(+) T lymphocytes (17.72%+/-2.4) infiltrating into the CNS at 7 days post-infection when compared to wild-type mice (31.02%+/-7.5). In addition, the L-sel(-/-) mice had significantly lower levels of TMEV-specific serum IgG resulting in lower virus neutralizing activity of the serum when compared to wild-type mice. However, the L-sel(-/-) mice had 2.5-fold increase in B lymphocytes in the CNS (8.29%+/-1.1) when compared to wild-type mice (3.2%+/-0.4). Taken together, these data indicate that L-selectin plays a role in recruitment of B and CD8(+) T lymphocytes into the CNS following virus infection, which, however, did not affect the ability of the mice to clear TMEV infection." @default.
• W2022405810 created "2016-06-24" @default.
• W2022405810 creator A5012581905 @default.
• W2022405810 creator A5022682897 @default.
• W2022405810 creator A5044624530 @default.
• W2022405810 creator A5045917422 @default.
• W2022405810 creator A5060299347 @default.
• W2022405810 creator A5071835265 @default.
• W2022405810 date "2001-06-01" @default.
• W2022405810 modified "2023-09-23" @default.
• W2022405810 title "Theiler's virus-infected l-selectin-deficient mice have decreased infiltration of CD8+ T lymphocytes in central nervous system but clear the virus" @default.
• W2022405810 cites W1480543173 @default.
• W2022405810 cites W1487256485 @default.
• W2022405810 cites W1492419138 @default.
• W2022405810 cites W1503421252 @default.
• W2022405810 cites W1503742489 @default.
• W2022405810 cites W1503771060 @default.
• W2022405810 cites W1509644032 @default.
• W2022405810 cites W1563668569 @default.
• W2022405810 cites W1645663089 @default.
• W2022405810 cites W1656874207 @default.
• W2022405810 cites W1768210657 @default.
• W2022405810 cites W186752733 @default.
• W2022405810 cites W1869309483 @default.
• W2022405810 cites W1912497605 @default.
• W2022405810 cites W1965788272 @default.
• W2022405810 cites W1966684157 @default.
• W2022405810 cites W1974210099 @default.
• W2022405810 cites W1975806365 @default.
• W2022405810 cites W1984535720 @default.
• W2022405810 cites W1993630351 @default.
• W2022405810 cites W1997349521 @default.
• W2022405810 cites W1997842962 @default.
• W2022405810 cites W2011685153 @default.
• W2022405810 cites W2029396088 @default.
• W2022405810 cites W2030100300 @default.
• W2022405810 cites W2042626190 @default.
• W2022405810 cites W2057040903 @default.
• W2022405810 cites W2061140050 @default.
• W2022405810 cites W2064267013 @default.
• W2022405810 cites W2080537082 @default.
• W2022405810 cites W2081954676 @default.
• W2022405810 cites W2090121937 @default.
• W2022405810 cites W2092830773 @default.
• W2022405810 cites W2109495817 @default.
• W2022405810 cites W2109916423 @default.
• W2022405810 cites W2114656277 @default.
• W2022405810 cites W2132134585 @default.
• W2022405810 cites W2140279098 @default.
• W2022405810 cites W2145397502 @default.
• W2022405810 cites W2147205708 @default.
• W2022405810 cites W2147306903 @default.
• W2022405810 cites W2152375760 @default.
• W2022405810 cites W2157924944 @default.
• W2022405810 cites W2162074059 @default.
• W2022405810 cites W4229901763 @default.
• W2022405810 doi "https://doi.org/10.1016/s0165-5728(01)00296-x" @default.
• W2022405810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11438172" @default.
• W2022405810 hasPublicationYear "2001" @default.
• W2022405810 type Work @default.
• W2022405810 sameAs 2022405810 @default.
• W2022405810 citedByCount "4" @default.
• W2022405810 crossrefType "journal-article" @default.
• W2022405810 hasAuthorship W2022405810A5012581905 @default.
• W2022405810 hasAuthorship W2022405810A5022682897 @default.
• W2022405810 hasAuthorship W2022405810A5044624530 @default.
• W2022405810 hasAuthorship W2022405810A5045917422 @default.
• W2022405810 hasAuthorship W2022405810A5060299347 @default.
• W2022405810 hasAuthorship W2022405810A5071835265 @default.
• W2022405810 hasConcept C121332964 @default.
• W2022405810 hasConcept C134018914 @default.
• W2022405810 hasConcept C153400128 @default.
• W2022405810 hasConcept C159047783 @default.
• W2022405810 hasConcept C167672396 @default.
• W2022405810 hasConcept C203014093 @default.
• W2022405810 hasConcept C2522874641 @default.
• W2022405810 hasConcept C529278444 @default.
• W2022405810 hasConcept C86803240 @default.
• W2022405810 hasConcept C8891405 @default.
• W2022405810 hasConcept C97355855 @default.
• W2022405810 hasConceptScore W2022405810C121332964 @default.
• W2022405810 hasConceptScore W2022405810C134018914 @default.
• W2022405810 hasConceptScore W2022405810C153400128 @default.
• W2022405810 hasConceptScore W2022405810C159047783 @default.
• W2022405810 hasConceptScore W2022405810C167672396 @default.
• W2022405810 hasConceptScore W2022405810C203014093 @default.
• W2022405810 hasConceptScore W2022405810C2522874641 @default.
• W2022405810 hasConceptScore W2022405810C529278444 @default.
• W2022405810 hasConceptScore W2022405810C86803240 @default.
• W2022405810 hasConceptScore W2022405810C8891405 @default.
• W2022405810 hasConceptScore W2022405810C97355855 @default.
• W2022405810 hasIssue "2" @default.
• W2022405810 hasLocation W20224058101 @default.
• W2022405810 hasLocation W20224058102 @default.
• W2022405810 hasOpenAccess W2022405810 @default.
• W2022405810 hasPrimaryLocation W20224058101 @default.
• W2022405810 hasRelatedWork W1702322095 @default.
• W2022405810 hasRelatedWork W1865764402 @default.

• next