Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022441454> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2022441454 endingPage "26" @default.
- W2022441454 startingPage "19" @default.
- W2022441454 abstract "Cochlear microperfusion will be a useful treatment of severe sensorineural hearing loss caused by inflammation.Viruses, bacteria, and autoimmunity can initiate inflammation in the inner ear. The acute phase is associated with elevations in cytokines, nitrous oxide, and cellular infiltrates and the breakdown of the blood-labyrinthine barrier. The chronic phase leads to irreversible ossification of the labyrinth.The authors developed cochlear microperfusion to facilitate removal of inflammatory cells and their byproducts during the acute phase of inflammation. Using a ventral approach to the guinea pig cochlea, the authors displaced resident perilymph by delivering perfusate into the scala vestibuli and collecting the effluent from the scala tympani. The authors evaluated the benefit of the procedure in an animal model of severe hearing loss caused by inflammation.Healthy controls undergoing cochlear microperfusion with phosphate-buffered saline incurred a mean hearing loss of 16 dB (n=4). This hearing loss was associated with the creation of two cochleostomies and not the perfusion itself. Sterile labyrinthitis (n=5) generated by perfusion of the cochlea with antigen consistently produced severe hearing loss over the initial 48 hours, and this hearing loss persisted for the subsequent 7 days. Therapeutic cochlear microperfusion, performed within the first 24 hours of developing severe hearing loss (n=9), immediately restored on average 24 dB (p <0.007) of hearing.Cochlear microperfusion is a promising new technique for treating severe deafness caused by inflammation. The benefit may be sustained when combined with local delivery of immunosuppressive agents to the inner ear." @default.
- W2022441454 created "2016-06-24" @default.
- W2022441454 creator A5029299234 @default.
- W2022441454 creator A5075072731 @default.
- W2022441454 creator A5075081952 @default.
- W2022441454 creator A5075164892 @default.
- W2022441454 date "2005-01-01" @default.
- W2022441454 modified "2023-09-24" @default.
- W2022441454 title "Cochlear Microperfusion: Experimental Evaluation of a Potential New Therapy for Severe Hearing Loss Caused by Inflammation" @default.
- W2022441454 cites W1971528716 @default.
- W2022441454 cites W1991300638 @default.
- W2022441454 cites W1995869519 @default.
- W2022441454 cites W2007632869 @default.
- W2022441454 cites W2023000404 @default.
- W2022441454 cites W2027222868 @default.
- W2022441454 cites W2033281822 @default.
- W2022441454 cites W2040976709 @default.
- W2022441454 cites W2044563281 @default.
- W2022441454 cites W2069141048 @default.
- W2022441454 cites W2069618340 @default.
- W2022441454 cites W2090980235 @default.
- W2022441454 cites W2092866020 @default.
- W2022441454 cites W2094211456 @default.
- W2022441454 cites W2095772895 @default.
- W2022441454 cites W2100754553 @default.
- W2022441454 cites W2100882276 @default.
- W2022441454 cites W2118697790 @default.
- W2022441454 cites W2119058219 @default.
- W2022441454 cites W2130683579 @default.
- W2022441454 cites W2137588072 @default.
- W2022441454 cites W2152587898 @default.
- W2022441454 cites W2164618476 @default.
- W2022441454 cites W2269089407 @default.
- W2022441454 doi "https://doi.org/10.1097/00129492-200501000-00005" @default.
- W2022441454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15699715" @default.
- W2022441454 hasPublicationYear "2005" @default.
- W2022441454 type Work @default.
- W2022441454 sameAs 2022441454 @default.
- W2022441454 citedByCount "9" @default.
- W2022441454 countsByYear W20224414542013 @default.
- W2022441454 countsByYear W20224414542014 @default.
- W2022441454 crossrefType "journal-article" @default.
- W2022441454 hasAuthorship W2022441454A5029299234 @default.
- W2022441454 hasAuthorship W2022441454A5075072731 @default.
- W2022441454 hasAuthorship W2022441454A5075081952 @default.
- W2022441454 hasAuthorship W2022441454A5075164892 @default.
- W2022441454 hasConcept C105702510 @default.
- W2022441454 hasConcept C126322002 @default.
- W2022441454 hasConcept C146957229 @default.
- W2022441454 hasConcept C203014093 @default.
- W2022441454 hasConcept C2776914184 @default.
- W2022441454 hasConcept C2777599811 @default.
- W2022441454 hasConcept C2778317342 @default.
- W2022441454 hasConcept C2778500370 @default.
- W2022441454 hasConcept C2780130748 @default.
- W2022441454 hasConcept C2780493683 @default.
- W2022441454 hasConcept C2780607864 @default.
- W2022441454 hasConcept C548259974 @default.
- W2022441454 hasConcept C71924100 @default.
- W2022441454 hasConceptScore W2022441454C105702510 @default.
- W2022441454 hasConceptScore W2022441454C126322002 @default.
- W2022441454 hasConceptScore W2022441454C146957229 @default.
- W2022441454 hasConceptScore W2022441454C203014093 @default.
- W2022441454 hasConceptScore W2022441454C2776914184 @default.
- W2022441454 hasConceptScore W2022441454C2777599811 @default.
- W2022441454 hasConceptScore W2022441454C2778317342 @default.
- W2022441454 hasConceptScore W2022441454C2778500370 @default.
- W2022441454 hasConceptScore W2022441454C2780130748 @default.
- W2022441454 hasConceptScore W2022441454C2780493683 @default.
- W2022441454 hasConceptScore W2022441454C2780607864 @default.
- W2022441454 hasConceptScore W2022441454C548259974 @default.
- W2022441454 hasConceptScore W2022441454C71924100 @default.
- W2022441454 hasIssue "1" @default.
- W2022441454 hasLocation W20224414541 @default.
- W2022441454 hasLocation W20224414542 @default.
- W2022441454 hasOpenAccess W2022441454 @default.
- W2022441454 hasPrimaryLocation W20224414541 @default.
- W2022441454 hasRelatedWork W1965917338 @default.
- W2022441454 hasRelatedWork W2022441454 @default.
- W2022441454 hasRelatedWork W2078683084 @default.
- W2022441454 hasRelatedWork W2114714426 @default.
- W2022441454 hasRelatedWork W2158084698 @default.
- W2022441454 hasRelatedWork W2164087417 @default.
- W2022441454 hasRelatedWork W2175904058 @default.
- W2022441454 hasRelatedWork W2341198027 @default.
- W2022441454 hasRelatedWork W4205476023 @default.
- W2022441454 hasRelatedWork W4214768940 @default.
- W2022441454 hasVolume "26" @default.
- W2022441454 isParatext "false" @default.
- W2022441454 isRetracted "false" @default.
- W2022441454 magId "2022441454" @default.
- W2022441454 workType "article" @default.