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• W2022441644 abstract "Unmethylated CpG motifs present in bacterial DNA are recognized by leucocyte receptors triggering an immune response. We have evaluated herein the immunomodulatory actions of a CpG motif in an important commercial fish, the gilthead seabream. Thus, 1, 3 and 7 days after intraperitoneal injection of the CpG motif the seabream immune parameters and gene expression profile were evaluated. Firstly, humoral innate immune responses were unaffected by CpG ODN 1668. On the other hand, ODN injection significantly enhanced the number of peritoneal leucocytes (PELs) 1 day after injection and increased the main innate immune parameters of PELs and HKLs (head-kidney leucocytes). Thus, injection of ODN 1668 significantly increased respiratory burst, peroxidase, cytotoxic and phagocytic activities, with variations in increment and time. The cytotoxic activity of HKLs was the most increased (up to 4.2-fold). Moreover, the expression profile of immune-relevant genes in head-kidney was affected, with substantial up-regulation of TLR9, IL-1β, Mx, TGFβ and Gal8 gene expression. These results demonstrate that unmethylated CpG motifs prime the fish immune response with promising applications for aquaculture." @default.
• W2022441644 created "2016-06-24" @default.
• W2022441644 creator A5041023617 @default.
• W2022441644 creator A5048150087 @default.
• W2022441644 creator A5053234208 @default.
• W2022441644 creator A5063715414 @default.
• W2022441644 date "2008-11-01" @default.
• W2022441644 modified "2023-10-16" @default.
• W2022441644 title "Unmethylated CpG motifs mimicking bacterial DNA triggers the local and systemic innate immune parameters and expression of immune-relevant genes in gilthead seabream" @default.
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• W2022441644 doi "https://doi.org/10.1016/j.fsi.2008.09.001" @default.
• W2022441644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18824235" @default.
• W2022441644 hasPublicationYear "2008" @default.
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