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• W2022443216 endingPage "103" @default.
• W2022443216 startingPage "95" @default.
• W2022443216 abstract "Electrical or chemical stimulation of the superior colliculus (SC) in rats produces orienting and defensive responses. Defensive behaviors are modulated by serotonin (5-hydroxytryptamine, 5-HT), and serotonergic fibers provide a dense innervation of the SC. Here, we examined the role of 5-HT in modulating the behavioral responses of rats elicited by electrical SC stimulation. Low-intensity (107+/-12 microA) stimulation of the SC elicited orienting head movements, while higher intensities (204+/-20 microA) produced running and jumping responses. Treatment with the 5-HT depletor p-chlorophenylalanine (300 mg/kg/day x 3, i.p.) lowered current thresholds to elicit orienting and running by 40 and 21%, respectively. Conversely, concurrent administration of the 5-HT uptake inhibitor fluoxetine (10 mg/kg, i.p.) and the 5-HT(1A) receptor antagonist WAY 100635 (0.5 mg/kg, s.c.) increased threshold currents to produce head and running movements by 41 and 18%, respectively. We investigated the anatomical substrate of this inhibitory effect of 5-HT with intracerebral 5-HT application by means of reverse microdialysis. Application of 5-HT (1-50 mM) into the midbrain immediately adjacent to the SC stimulation electrode resulted in a pronounced (approximately four-fold for 50 mM 5-HT) dose- and time-dependent increase in stimulation thresholds to elicit head movements. Application of 5-HT into the frontal cortex (up to 100 mM) had no significant effect on SC-evoked behavioral responses. These results show that 5-HT exerts an inhibitory influence over orienting and defensive behaviors initiated in the mammalian SC. It appears that this inhibitory effect is mediated, to a large extent, by a direct action of 5-HT at the level of the midbrain." @default.
• W2022443216 created "2016-06-24" @default.
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• W2022443216 date "2003-09-01" @default.
• W2022443216 modified "2023-10-11" @default.
• W2022443216 title "Orienting and defensive behaviors elicited by superior colliculus stimulation in rats: effects of 5-HT depletion, uptake inhibition, and direct midbrain or frontal cortex application" @default.
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• W2022443216 doi "https://doi.org/10.1016/s0166-4328(03)00065-2" @default.
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