FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022452013> ?p ?o ?g. }

• W2022452013 endingPage "e19191" @default.
• W2022452013 startingPage "e19191" @default.
• W2022452013 abstract "Amyloid beta (Aβ) peptide accumulation in the brains of patients with Alzheimer's disease (AD) is closely associated with increased nerve cell death. However, many cells survive and it is important to understand the mechanisms involved in this survival response. Recent studies have shown that an anti-apoptotic mechanism in cancer cells is mediated by aerobic glycolysis, also known as the Warburg effect. One of the major regulators of aerobic glycolysis is pyruvate dehydrogenase kinase (PDK), an enzyme which represses mitochondrial respiration and forces the cell to rely heavily on glycolysis, even in the presence of oxygen. Recent neuroimaging studies have shown that the spatial distribution of aerobic glycolysis in the brains of AD patients strongly correlates with Aβ deposition. Interestingly, clonal nerve cell lines selected for resistance to Aβ exhibit increased glycolysis as a result of activation of the transcription factor hypoxia inducible factor 1. Here we show that Aβ resistant nerve cell lines upregulate Warburg effect enzymes in a manner reminiscent of cancer cells. In particular, Aβ resistant nerve cell lines showed elevated PDK1 expression in addition to an increase in lactate dehydrogenase A (LDHA) activity and lactate production when compared to control cells. In addition, mitochondrial derived reactive oxygen species (ROS) were markedly diminished in resistant but not sensitive cells. Chemically or genetically inhibiting LDHA or PDK1 re-sensitized resistant cells to Aβ toxicity. These findings suggest that the Warburg effect may contribute to apoptotic-resistance mechanisms in the surviving neurons of the AD brain. Loss of the adaptive advantage afforded by aerobic glycolysis may exacerbate the pathophysiological processes associated with AD." @default.
• W2022452013 created "2016-06-24" @default.
• W2022452013 creator A5011625857 @default.
• W2022452013 creator A5012958593 @default.
• W2022452013 creator A5028217658 @default.
• W2022452013 creator A5070353325 @default.
• W2022452013 creator A5071774128 @default.
• W2022452013 creator A5072742742 @default.
• W2022452013 date "2011-04-26" @default.
• W2022452013 modified "2023-10-10" @default.
• W2022452013 title "Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect" @default.
• W2022452013 cites W1483086522 @default.
• W2022452013 cites W1503983308 @default.
• W2022452013 cites W1510940454 @default.
• W2022452013 cites W1531051436 @default.
• W2022452013 cites W1591646293 @default.
• W2022452013 cites W1970587959 @default.
• W2022452013 cites W1980842500 @default.
• W2022452013 cites W1982107902 @default.
• W2022452013 cites W1984832858 @default.
• W2022452013 cites W1985584416 @default.
• W2022452013 cites W1989462226 @default.
• W2022452013 cites W1995650022 @default.
• W2022452013 cites W1998042659 @default.
• W2022452013 cites W2006007524 @default.
• W2022452013 cites W2010394923 @default.
• W2022452013 cites W2018354461 @default.
• W2022452013 cites W2018971639 @default.
• W2022452013 cites W2024683111 @default.
• W2022452013 cites W2027705428 @default.
• W2022452013 cites W2029205666 @default.
• W2022452013 cites W2029552699 @default.
• W2022452013 cites W2030333049 @default.
• W2022452013 cites W2033710792 @default.
• W2022452013 cites W2033958147 @default.
• W2022452013 cites W2034661401 @default.
• W2022452013 cites W2035983112 @default.
• W2022452013 cites W2036910361 @default.
• W2022452013 cites W2038009564 @default.
• W2022452013 cites W2040929937 @default.
• W2022452013 cites W2044136163 @default.
• W2022452013 cites W2046798812 @default.
• W2022452013 cites W2046847750 @default.
• W2022452013 cites W2048706307 @default.
• W2022452013 cites W2049192526 @default.
• W2022452013 cites W2050140657 @default.
• W2022452013 cites W2054526986 @default.
• W2022452013 cites W2057975086 @default.
• W2022452013 cites W2058691572 @default.
• W2022452013 cites W2066238589 @default.
• W2022452013 cites W2074521739 @default.
• W2022452013 cites W2079598623 @default.
• W2022452013 cites W2092800106 @default.
• W2022452013 cites W2094006219 @default.
• W2022452013 cites W2100723895 @default.
• W2022452013 cites W2102117809 @default.
• W2022452013 cites W2102526923 @default.
• W2022452013 cites W2103024032 @default.
• W2022452013 cites W2123619340 @default.
• W2022452013 cites W2123716968 @default.
• W2022452013 cites W2130503287 @default.
• W2022452013 cites W2137243283 @default.
• W2022452013 cites W2141627190 @default.
• W2022452013 cites W2151260260 @default.
• W2022452013 cites W2158748165 @default.
• W2022452013 cites W2163471981 @default.
• W2022452013 cites W2168937351 @default.
• W2022452013 cites W4243903519 @default.
• W2022452013 doi "https://doi.org/10.1371/journal.pone.0019191" @default.
• W2022452013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3082554" @default.
• W2022452013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21541279" @default.
• W2022452013 hasPublicationYear "2011" @default.
• W2022452013 type Work @default.
• W2022452013 sameAs 2022452013 @default.
• W2022452013 citedByCount "95" @default.
• W2022452013 countsByYear W20224520132012 @default.
• W2022452013 countsByYear W20224520132013 @default.
• W2022452013 countsByYear W20224520132014 @default.
• W2022452013 countsByYear W20224520132015 @default.
• W2022452013 countsByYear W20224520132016 @default.
• W2022452013 countsByYear W20224520132017 @default.
• W2022452013 countsByYear W20224520132018 @default.
• W2022452013 countsByYear W20224520132019 @default.
• W2022452013 countsByYear W20224520132020 @default.
• W2022452013 countsByYear W20224520132021 @default.
• W2022452013 countsByYear W20224520132022 @default.
• W2022452013 countsByYear W20224520132023 @default.
• W2022452013 crossrefType "journal-article" @default.
• W2022452013 hasAuthorship W2022452013A5011625857 @default.
• W2022452013 hasAuthorship W2022452013A5012958593 @default.
• W2022452013 hasAuthorship W2022452013A5028217658 @default.
• W2022452013 hasAuthorship W2022452013A5070353325 @default.
• W2022452013 hasAuthorship W2022452013A5071774128 @default.
• W2022452013 hasAuthorship W2022452013A5072742742 @default.
• W2022452013 hasBestOaLocation W20224520131 @default.
• W2022452013 hasConcept C109156525 @default.
• W2022452013 hasConcept C121608353 @default.
• W2022452013 hasConcept C181199279 @default.

• next