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- W2022453303 abstract "Vigabatrin, usually as add on-therapy, was given to 52 patients with drug resistant symptomatic epilepsies and complex-focal as well as in most patients additional secondarily generalized tonic-clonic seizures and mental retardation and/or other neuropsychiatric deficits in the age between 3;8 and 28;8 years. Initially 31 % of the patients were regarded as responders. However, more than half of them demonstrated a development of tolerance to the effect of vigabatrin within 2 years leading to 10-15% long-term responders. The general tolerability of vigabatrin was very good and there were no pathological changes of laboratory values. Relevant side effects were observed as provocation of generalized tonic-clonic seizures (in 20 %), exogenous and after discontinuation of the drug reversible psychoses (in 5 patients, 4 of whom had an history with earlier episodes or disposition) and as effects of an interaction with other antiepileptic drugs, being managable by dose modifications." @default.
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- W2022453303 date "1992-09-01" @default.
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- W2022453303 title "Vigabatrin-Langzeittherapie bei symptomatischen Epilepsien mit komplex-fokalen Anfällen im Kindesalter" @default.
- W2022453303 doi "https://doi.org/10.1055/s-2007-1018074" @default.
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