FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022458997> ?p ?o ?g. }

• W2022458997 endingPage "398" @default.
• W2022458997 startingPage "387" @default.
• W2022458997 abstract "Lactoferrin (LF) is a multifunctional glycoprotein that plays an important role in native immune defense against infections, including human herpetic viruses, such as cytomegalovirus and herpes simplex virus types 1 and 2. However, its anti-Epstein-Barr virus (EBV, a γ-herpesvirus) function has not been reported in the literature. EBV is widespread in all human populations and is believed to be linked to tumorigenesis, such as lymphomas and nasopharyngeal carcinoma (NPC). We previously reported that LF expressed a significantly lower level in NPC tissues and was a likely tumor suppressor. Since EBV infection is a major carcinogen of NPC development, we investigated the effect of LF on EBV infection and found that LF could protect human primary B lymphocytes and nasopharyngeal epithelial cells from EBV infection, but had no effect on EBV genome DNA replication. LF prevented EBV infection of primary B cells mediated by its direct binding to the EBV receptor (CD21) on the B-cell surface. Tissue array immunohistochemistry revealed that LF expression was significantly downregulated in NPC specimens, in which high EBV viral capsid antigen-IgA levels were observed. These data suggest that LF may inhibit EBV infection and that its downregulation could contribute to NPC development." @default.
• W2022458997 created "2016-06-24" @default.
• W2022458997 creator A5001873226 @default.
• W2022458997 creator A5010319430 @default.
• W2022458997 creator A5026091430 @default.
• W2022458997 creator A5028424745 @default.
• W2022458997 creator A5031812121 @default.
• W2022458997 creator A5032162374 @default.
• W2022458997 creator A5036903229 @default.
• W2022458997 creator A5049396596 @default.
• W2022458997 creator A5051334432 @default.
• W2022458997 creator A5065058975 @default.
• W2022458997 creator A5066598654 @default.
• W2022458997 creator A5073699686 @default.
• W2022458997 creator A5076563235 @default.
• W2022458997 creator A5086543492 @default.
• W2022458997 creator A5089672794 @default.
• W2022458997 creator A5090350458 @default.
• W2022458997 date "2012-01-01" @default.
• W2022458997 modified "2023-10-14" @default.
• W2022458997 title "Inhibition of Epstein-Barr Virus Infection by Lactoferrin" @default.
• W2022458997 cites W1578954095 @default.
• W2022458997 cites W1579336178 @default.
• W2022458997 cites W1927596245 @default.
• W2022458997 cites W1967430000 @default.
• W2022458997 cites W1987387229 @default.
• W2022458997 cites W1988554751 @default.
• W2022458997 cites W1991300982 @default.
• W2022458997 cites W1994275881 @default.
• W2022458997 cites W2000409833 @default.
• W2022458997 cites W2006487854 @default.
• W2022458997 cites W2012875852 @default.
• W2022458997 cites W2016828201 @default.
• W2022458997 cites W2019022416 @default.
• W2022458997 cites W2023628817 @default.
• W2022458997 cites W2026540826 @default.
• W2022458997 cites W2030022561 @default.
• W2022458997 cites W2052199417 @default.
• W2022458997 cites W2052374539 @default.
• W2022458997 cites W2061085356 @default.
• W2022458997 cites W2065594827 @default.
• W2022458997 cites W2074795687 @default.
• W2022458997 cites W2077367762 @default.
• W2022458997 cites W2082977718 @default.
• W2022458997 cites W2119900141 @default.
• W2022458997 cites W2124503827 @default.
• W2022458997 cites W2127086165 @default.
• W2022458997 cites W2128681927 @default.
• W2022458997 cites W2137624477 @default.
• W2022458997 cites W2141806110 @default.
• W2022458997 cites W2146022747 @default.
• W2022458997 cites W2150668424 @default.
• W2022458997 cites W2152034155 @default.
• W2022458997 cites W2159664205 @default.
• W2022458997 cites W2163510698 @default.
• W2022458997 cites W2163682706 @default.
• W2022458997 cites W2164584921 @default.
• W2022458997 cites W2386044720 @default.
• W2022458997 doi "https://doi.org/10.1159/000336178" @default.
• W2022458997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6741539" @default.
• W2022458997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22433582" @default.
• W2022458997 hasPublicationYear "2012" @default.
• W2022458997 type Work @default.
• W2022458997 sameAs 2022458997 @default.
• W2022458997 citedByCount "32" @default.
• W2022458997 countsByYear W20224589972013 @default.
• W2022458997 countsByYear W20224589972014 @default.
• W2022458997 countsByYear W20224589972016 @default.
• W2022458997 countsByYear W20224589972017 @default.
• W2022458997 countsByYear W20224589972018 @default.
• W2022458997 countsByYear W20224589972019 @default.
• W2022458997 countsByYear W20224589972020 @default.
• W2022458997 countsByYear W20224589972021 @default.
• W2022458997 countsByYear W20224589972022 @default.
• W2022458997 crossrefType "journal-article" @default.
• W2022458997 hasAuthorship W2022458997A5001873226 @default.
• W2022458997 hasAuthorship W2022458997A5010319430 @default.
• W2022458997 hasAuthorship W2022458997A5026091430 @default.
• W2022458997 hasAuthorship W2022458997A5028424745 @default.
• W2022458997 hasAuthorship W2022458997A5031812121 @default.
• W2022458997 hasAuthorship W2022458997A5032162374 @default.
• W2022458997 hasAuthorship W2022458997A5036903229 @default.
• W2022458997 hasAuthorship W2022458997A5049396596 @default.
• W2022458997 hasAuthorship W2022458997A5051334432 @default.
• W2022458997 hasAuthorship W2022458997A5065058975 @default.
• W2022458997 hasAuthorship W2022458997A5066598654 @default.
• W2022458997 hasAuthorship W2022458997A5073699686 @default.
• W2022458997 hasAuthorship W2022458997A5076563235 @default.
• W2022458997 hasAuthorship W2022458997A5086543492 @default.
• W2022458997 hasAuthorship W2022458997A5089672794 @default.
• W2022458997 hasAuthorship W2022458997A5090350458 @default.
• W2022458997 hasBestOaLocation W20224589971 @default.
• W2022458997 hasConcept C104317684 @default.
• W2022458997 hasConcept C126322002 @default.
• W2022458997 hasConcept C147483822 @default.
• W2022458997 hasConcept C159047783 @default.
• W2022458997 hasConcept C203014093 @default.
• W2022458997 hasConcept C2522874641 @default.

• next