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• W2022460908 abstract "Two new pentacyclic triterpenes named kirmanoic acid ( 1 ) and kurramanoic acid ( 2 ) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their 1 H and 13 C NMR spectra including two-dimensional NMR techniques such as COSY, HMQC, and HMBC experiments. Kirmanoic acid ( 1 ) was investigated for analgesic, anti-inflammatory, and CNS depressant activities. Interestingly kirmanoic acid ( 1 ) showed strong analgesic activity than standard drug in acetic induced writhing and formalin tests. Similarly kirmanoic acid ( 1 ) also showed strong anti-inflammatory activity than its standard drug. The gross behavioral study of kirmanoic acid ( 1 ) revealed that it exhibited mild CNS stimulant and muscle relaxant in the mice. Compound 1 showed a slight increase in Locomotor activity and possesses the antidepressant effect" @default.
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• W2022460908 date "2012-04-01" @default.
• W2022460908 modified "2023-09-26" @default.
• W2022460908 title "Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei" @default.
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• W2022460908 doi "https://doi.org/10.1016/j.fitote.2012.01.002" @default.
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