FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022461773> ?p ?o ?g. }

• W2022461773 endingPage "71" @default.
• W2022461773 startingPage "62" @default.
• W2022461773 abstract "Background Leptin and ghrelin are increasingly being recognized as cardiotropic hormones, promoting or inhibiting the atherosclerotic process, respectively. Apoptosis may be one pathway through which the actions of these hormones are mediated. Sex hormones are reported to influence the secretion and action of ghrelin and leptin. Objective To evaluate (1) the association of circulating ghrelin and leptin with selected markers of receptor-mediated apoptosis and (2) the effect of estrogen monotherapy, low dose estrogen–progestin therapy, tibolone and raloxifene on serum ghrelin and leptin in healthy postmenopausal women. Methods Eighty eight postmenopausal women aged 44–62 years were randomly allocated to daily (1) conjugated equine estrogens 0.625 mg (CEE), (2) 17β-estradiol 1 mg plus norethisterone acetate 0.5 mg (E2/NETA), (3) tibolone 2.5 mg, (4) raloxifene HCl 60 mg or (5) no treatment. Serum markers of apoptosis sFas, Fas-ligand (Fas-L) and caspase-1 were measured at baseline. Serum leptin and ghrelin were measured at baseline and at 3 months. Results Body Mass Index (BMI) and estradiol levels correlated positively, while FSH correlated negatively with serum leptin (BMI: r = 0.646, p = 0.005, estradiol: r = 0.432, p = 0.001, FSH: r = −0.401, p = 0.002). Insulin levels associated positively with circulating leptin (r = 0.394, p = 0.011) and negatively with circulating ghrelin (r = −0.401, p = 0.009). Serum leptin decreased significantly in E2/NETA group (baseline: 2.882 ± 0.76 ng/ml, 3 months: 2.687 ± 0.66 ng/ml, p = 0.043), while it increased significantly in the raloxifene group (baseline: 2.671 ± 0.54 ng/ml, 3 months: 2.839 ± 0.47 ng/ml). Ghrelin levels decreased significantly only in the raloxifene group (baseline: 1634 ± 592 pg/ml, 3 months: 1408 ± 534 pg/ml). Conclusion Apoptosis may be a pathway through which leptin exerts a pro-atherogenic effect. Low dose HT may act carioprotectively by decreasing letpin levels in healthy recently menopaused women." @default.
• W2022461773 created "2016-06-24" @default.
• W2022461773 creator A5000459159 @default.
• W2022461773 creator A5010142961 @default.
• W2022461773 creator A5017069281 @default.
• W2022461773 creator A5034510665 @default.
• W2022461773 creator A5071382934 @default.
• W2022461773 creator A5083862481 @default.
• W2022461773 creator A5084991470 @default.
• W2022461773 creator A5066110511 @default.
• W2022461773 date "2008-01-01" @default.
• W2022461773 modified "2023-09-27" @default.
• W2022461773 title "Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene" @default.
• W2022461773 cites W1593442063 @default.
• W2022461773 cites W1616806865 @default.
• W2022461773 cites W1631449371 @default.
• W2022461773 cites W174419708 @default.
• W2022461773 cites W1898391394 @default.
• W2022461773 cites W1901716085 @default.
• W2022461773 cites W1939446637 @default.
• W2022461773 cites W1964828358 @default.
• W2022461773 cites W1970503128 @default.
• W2022461773 cites W1971055570 @default.
• W2022461773 cites W1971207502 @default.
• W2022461773 cites W1973614015 @default.
• W2022461773 cites W1978496847 @default.
• W2022461773 cites W1978955123 @default.
• W2022461773 cites W1979169741 @default.
• W2022461773 cites W1980089856 @default.
• W2022461773 cites W1982853778 @default.
• W2022461773 cites W1983080612 @default.
• W2022461773 cites W1985582087 @default.
• W2022461773 cites W1990692512 @default.
• W2022461773 cites W2005259683 @default.
• W2022461773 cites W2014124599 @default.
• W2022461773 cites W2019265621 @default.
• W2022461773 cites W2019361383 @default.
• W2022461773 cites W2024853089 @default.
• W2022461773 cites W2031481579 @default.
• W2022461773 cites W2033136281 @default.
• W2022461773 cites W2041363426 @default.
• W2022461773 cites W2043206052 @default.
• W2022461773 cites W2048005182 @default.
• W2022461773 cites W2048257551 @default.
• W2022461773 cites W2051633109 @default.
• W2022461773 cites W2055075631 @default.
• W2022461773 cites W2063052824 @default.
• W2022461773 cites W2063867076 @default.
• W2022461773 cites W2072594041 @default.
• W2022461773 cites W2073184302 @default.
• W2022461773 cites W2073675322 @default.
• W2022461773 cites W2076458518 @default.
• W2022461773 cites W2077046340 @default.
• W2022461773 cites W2078303139 @default.
• W2022461773 cites W2078878902 @default.
• W2022461773 cites W2087782544 @default.
• W2022461773 cites W2099172421 @default.
• W2022461773 cites W2102790142 @default.
• W2022461773 cites W2105573142 @default.
• W2022461773 cites W2107261012 @default.
• W2022461773 cites W2108112484 @default.
• W2022461773 cites W2108481121 @default.
• W2022461773 cites W2111419555 @default.
• W2022461773 cites W2113264115 @default.
• W2022461773 cites W2114196318 @default.
• W2022461773 cites W2126426760 @default.
• W2022461773 cites W2129928030 @default.
• W2022461773 cites W2134407603 @default.
• W2022461773 cites W2141990430 @default.
• W2022461773 cites W2143015087 @default.
• W2022461773 cites W2147184135 @default.
• W2022461773 cites W2147772037 @default.
• W2022461773 cites W2148072257 @default.
• W2022461773 cites W2149252002 @default.
• W2022461773 cites W2153300276 @default.
• W2022461773 cites W2155478471 @default.
• W2022461773 cites W2157049105 @default.
• W2022461773 cites W2165670397 @default.
• W2022461773 cites W2168156339 @default.
• W2022461773 cites W2171921796 @default.
• W2022461773 cites W2323115783 @default.
• W2022461773 cites W2329406962 @default.
• W2022461773 cites W4242307621 @default.
• W2022461773 cites W4243712281 @default.
• W2022461773 cites W4252489788 @default.
• W2022461773 cites W3141782761 @default.
• W2022461773 doi "https://doi.org/10.1016/j.maturitas.2007.10.003" @default.
• W2022461773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18164562" @default.
• W2022461773 hasPublicationYear "2008" @default.
• W2022461773 type Work @default.
• W2022461773 sameAs 2022461773 @default.
• W2022461773 citedByCount "20" @default.
• W2022461773 countsByYear W20224617732012 @default.
• W2022461773 countsByYear W20224617732013 @default.
• W2022461773 countsByYear W20224617732014 @default.
• W2022461773 countsByYear W20224617732015 @default.
• W2022461773 countsByYear W20224617732016 @default.
• W2022461773 countsByYear W20224617732017 @default.

• next