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- W2022474898 abstract "HIV-1 transcription is regulated by CDK9/cyclin T1, which, unlike a typical cell cycle-dependent kinase, is regulated by associating with 7SK small nuclear ribonuclear protein complex (snRNP). While the protein components of this complex are well studied, the mechanism of the complex formation is still not fully understood. The association of CDK9/cyclin T1 with 7SK snRNP is, in part, regulated by a reversible CDK9 phosphorylation. Here, we present a comprehensive review of the kinases and phosphatases involved in CDK9 phosphorylation and discuss their role in regulation of HIV-1 replication and potential for being targeted for drug development. We propose a novel pathway of HIV-1 transcription regulation via CDK9 Ser-90 phosphorylation by CDK2 and CDK9 Ser-175 dephosphorylation by protein phosphatase-1." @default.
- W2022474898 created "2016-06-24" @default.
- W2022474898 creator A5025205189 @default.
- W2022474898 creator A5076357882 @default.
- W2022474898 creator A5078357534 @default.
- W2022474898 date "2014-01-01" @default.
- W2022474898 modified "2023-10-15" @default.
- W2022474898 title "Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation" @default.
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- W2022474898 doi "https://doi.org/10.1155/2014/964964" @default.
- W2022474898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3913462" @default.
- W2022474898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24524087" @default.
- W2022474898 hasPublicationYear "2014" @default.
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