FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022486543> ?p ?o ?g. }

• W2022486543 endingPage "158" @default.
• W2022486543 startingPage "149" @default.
• W2022486543 abstract "Fanconi anemia (FA) is an inherited disease characterized by bone marrow failure, increased cancer risk and hypersensitivity to DNA cross-linking agents, implying a role for this pathway in the maintenance of genomic stability. The central player of the FA pathway is the multi-subunit E3 ubiquitin ligase complex activated through a replication- and DNA damage-dependent mechanism. A consequence of the activation of the complex is the monoubiquitylation of FANCD2 and FANCI, late term effectors in the maintenance of genome integrity. The details regarding the coordination of the FA-dependent response and the DNA replication process are still mostly unknown. We found, by yeast two-hybrid assay and co-immunoprecipitation in human cells, that the core complex subunit FANCF physically interacts with PSF2, a member of the GINS complex essential for both the initiation and elongation steps of DNA replication. In HeLa cells depleted for PSF2, we observed a decreased binding to chromatin of the FA core complex, suggesting that the GINS complex may have a role in either loading or stabilizing the FA core complex onto chromatin. Consistently, GINS and core complex bind chromatin contemporarily upon origin firing and PSF2 depletion sensitizes cells to DNA cross-linking agents. However, depletion of PSF2 is not sufficient to reduce monoubiquitylation of FANCD2 or its localization to nuclear foci following DNA damage. Our results suggest a novel crosstalk between DNA replication and the FA pathway." @default.
• W2022486543 created "2016-06-24" @default.
• W2022486543 creator A5031255132 @default.
• W2022486543 creator A5063018109 @default.
• W2022486543 creator A5079441394 @default.
• W2022486543 creator A5090005913 @default.
• W2022486543 date "2011-02-01" @default.
• W2022486543 modified "2023-10-16" @default.
• W2022486543 title "Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex" @default.
• W2022486543 cites W1775050147 @default.
• W2022486543 cites W1965495050 @default.
• W2022486543 cites W1965749659 @default.
• W2022486543 cites W1969171797 @default.
• W2022486543 cites W1974993967 @default.
• W2022486543 cites W1979324654 @default.
• W2022486543 cites W1990734482 @default.
• W2022486543 cites W1991591616 @default.
• W2022486543 cites W1993913655 @default.
• W2022486543 cites W2010216792 @default.
• W2022486543 cites W2010444982 @default.
• W2022486543 cites W2015012409 @default.
• W2022486543 cites W2025840928 @default.
• W2022486543 cites W2028767678 @default.
• W2022486543 cites W2034200436 @default.
• W2022486543 cites W2034747770 @default.
• W2022486543 cites W2036716410 @default.
• W2022486543 cites W2039641528 @default.
• W2022486543 cites W2041473497 @default.
• W2022486543 cites W2044292152 @default.
• W2022486543 cites W2053779322 @default.
• W2022486543 cites W2054203098 @default.
• W2022486543 cites W2056068841 @default.
• W2022486543 cites W2057637765 @default.
• W2022486543 cites W2058703060 @default.
• W2022486543 cites W2071605741 @default.
• W2022486543 cites W2071993841 @default.
• W2022486543 cites W2082507962 @default.
• W2022486543 cites W2083733781 @default.
• W2022486543 cites W2084310601 @default.
• W2022486543 cites W2088374322 @default.
• W2022486543 cites W2089258879 @default.
• W2022486543 cites W2096048754 @default.
• W2022486543 cites W2101185225 @default.
• W2022486543 cites W2101794075 @default.
• W2022486543 cites W2108077889 @default.
• W2022486543 cites W2110817748 @default.
• W2022486543 cites W2114776482 @default.
• W2022486543 cites W2114907977 @default.
• W2022486543 cites W2116111997 @default.
• W2022486543 cites W2120357332 @default.
• W2022486543 cites W2121980126 @default.
• W2022486543 cites W2132587601 @default.
• W2022486543 cites W2134156532 @default.
• W2022486543 cites W2140336382 @default.
• W2022486543 cites W2145079065 @default.
• W2022486543 cites W2150152073 @default.
• W2022486543 cites W2156585570 @default.
• W2022486543 cites W2162221778 @default.
• W2022486543 cites W2163419736 @default.
• W2022486543 cites W2163599181 @default.
• W2022486543 cites W2166221950 @default.
• W2022486543 cites W2170609809 @default.
• W2022486543 doi "https://doi.org/10.1016/j.dnarep.2010.10.006" @default.
• W2022486543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21109493" @default.
• W2022486543 hasPublicationYear "2011" @default.
• W2022486543 type Work @default.
• W2022486543 sameAs 2022486543 @default.
• W2022486543 citedByCount "15" @default.
• W2022486543 countsByYear W20224865432012 @default.
• W2022486543 countsByYear W20224865432013 @default.
• W2022486543 countsByYear W20224865432014 @default.
• W2022486543 countsByYear W20224865432015 @default.
• W2022486543 countsByYear W20224865432017 @default.
• W2022486543 countsByYear W20224865432018 @default.
• W2022486543 countsByYear W20224865432019 @default.
• W2022486543 countsByYear W20224865432022 @default.
• W2022486543 crossrefType "journal-article" @default.
• W2022486543 hasAuthorship W2022486543A5031255132 @default.
• W2022486543 hasAuthorship W2022486543A5063018109 @default.
• W2022486543 hasAuthorship W2022486543A5079441394 @default.
• W2022486543 hasAuthorship W2022486543A5090005913 @default.
• W2022486543 hasConcept C120665830 @default.
• W2022486543 hasConcept C121332964 @default.
• W2022486543 hasConcept C134935766 @default.
• W2022486543 hasConcept C143425029 @default.
• W2022486543 hasConcept C151158763 @default.
• W2022486543 hasConcept C169822122 @default.
• W2022486543 hasConcept C175193931 @default.
• W2022486543 hasConcept C178169997 @default.
• W2022486543 hasConcept C2776653068 @default.
• W2022486543 hasConcept C2778124228 @default.
• W2022486543 hasConcept C41141232 @default.
• W2022486543 hasConcept C54355233 @default.
• W2022486543 hasConcept C552990157 @default.
• W2022486543 hasConcept C73573662 @default.
• W2022486543 hasConcept C83640560 @default.
• W2022486543 hasConcept C86803240 @default.
• W2022486543 hasConcept C95444343 @default.

• next